Skip to main content

Advertisement

Log in

Maintenance of whole-body therapeutic hypothermia during patient transport and magnetic resonance imaging

  • Technical Innovation
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Therapeutic hypothermia has become standard treatment for neonatal hypoxic–ischemic encephalopathy (HIE), with brain MRI commonly performed after the child has been rewarmed. However, early imaging during hypothermia might provide information important in designing clinical trials that refine and personalize therapeutic hypothermia. We tested a protocol to ensure safety and maintenance of hypothermia during in-hospital transport and MRI. MRI during therapeutic hypothermia was performed in 13 newborns on the 2nd-3rd postnatal days. Mean one-way transport time was 20.0 ± 3.3 min. Mean rectal temperatures (°C) leaving the unit, upon arrival at the MR suite, during MRI scan and upon return to the unit were 33.5 ± 0.3°C, 33.3 ± 0.3°C, 33.1 ± 0.4°C and 33.4 ± 0.3°C, respectively. Using our protocol therapeutic hypothermia was safely and effectively continued during in-hospital transport and MRI without adverse effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. De Vries LS, Jongmans MJ (2010) Long-term outcome after neonatal hypoxic–ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 95:F220–F224

    Article  PubMed  Google Scholar 

  2. Shankaran S, Pappas A, McDonald SA et al (2012) Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 366:2085–2092

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Neil J (2010) Is MRI still cool after hypothermia? Lancet Neurol 9:19–20

    Article  PubMed  Google Scholar 

  4. Wintermark P, Hansen A, Soul J et al (2011) Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch Dis Child Fetal Neonatal Ed 96:F36–F44

    Article  PubMed Central  PubMed  Google Scholar 

  5. Wintermark P, Labrecque M, Warfield SK et al (2010) Can induced hypothermia be assured during brain MRI in neonates with hypoxic–ischemic encephalopathy? Pediatr Radiol 40:1950–1954

    Article  PubMed Central  PubMed  Google Scholar 

  6. Rutherford M, Srinivasan L, Dyet L et al (2006) Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome. Pediatr Radiol 36:582–592

    Article  PubMed  Google Scholar 

  7. Corbett RJ, Laptook AR, Tollefsbol G et al (1995) Validation of a noninvasive method to measure brain temperature in vivo using 1H NMR spectroscopy. J Neurochem 64:1224–1230

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tai-Wei Wu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wu, TW., McLean, C., Friedlich, P. et al. Maintenance of whole-body therapeutic hypothermia during patient transport and magnetic resonance imaging. Pediatr Radiol 44, 613–617 (2014). https://doi.org/10.1007/s00247-013-2863-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-013-2863-2

Keywords

Navigation