Abstract
The relations of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to microvessel density (MVD), histologic grade, and presence of metastasis were evaluated to establish new prognostic indicators in colorectal cancer (CRC). Fast-low angle shot DCE-MRI parameters (time-intensity curves, TICs; maximal relative enhancement within the first minute, Emax/1; maximal relative enhancement of the entire study, Emax; steepest slope of the contrast enhancement curve; and time to peak enhancement) of 21 CRCs (seven Duke stage B, 12 Duke stage C, and two Duke stage D) were retrospectively evaluated and correlated with corresponding postoperative MVD measurements, histologic grades, and presence of metastasis at 2 years. TICs were classified as type A in nine (43%), type B in seven (33%), and type C in five cases (24%). There was a significant difference between TIC types with regard to MVD (p < 0.05–0.001). Time to peak enhancement, steepest slope of TIC, and Emax/1 were strongly correlated with MVD (r = −0.765, p < 0.01; r = 0.681, p < 0.01; r = 0.634, p < 0.01; respectively). MVD, steepest slope of the enhancement curve, Emax/1, and Emax strongly correlated with histologic grade (r = 0.475, p < 0.05; r = 0.683, p < 0.01; r = 0.687, p < 0.01; r = 0.791, p < 0.01; respectively). There was a significant difference between groups of patients with and without metastasis with regard to histologic grade (p < 0.05) and two of the DCE-MRI parameters (p < 0.005 for Emax/1 and p < 0.05 for time to peak enhancement). Discriminant analysis correctly predicted the metastatic occurrence at 2 years in 90.5% of cases using Emax/1 (p < 0.001). Histologic grade resulted in lower rates of discrimination (66.7%; p < 0.05). DCE-MRI parameters may help in the prediction of MVD and histologic grade in CRC and may be used to predict therapeutic outcome.
Similar content being viewed by others
References
JWAJ Readers (2001) ArticleTitleNeoplastic and inflammatory disease of the colon. Eur Radiol 11 IssueIDsuppl 2 105–126
AF DeVries J Griebel C Kremser et al. (2001) ArticleTitleTumor microcirculation evaluated by dynamic magnetic resonance imaging predicts therapy outcome for primary rectal carcinoma. Cancer Res 15 2513–2516
N Weidner JP Semple WR Welch J Folkman (1991) ArticleTitleTumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Eng J Med 324 1–8 Occurrence Handle10.1056/NEJM199101033240101 Occurrence Handle1:STN:280:DyaK3M%2FnsVWquw%3D%3D
N Weidner PR Carroll J Flax et al. (1993) ArticleTitleTumor angiogenesis correlates with metastases in invasive prostat carcinoma. Am J Pathol 143 401–409 Occurrence Handle7688183 Occurrence Handle1:STN:280:DyaK3szktlWqtQ%3D%3D
K Maeda YS Chung S Takatsuka et al. (1995) ArticleTitleTumor angiogenesis as a predictor of recurrence in gastric carcinoma. J Clin Oncol 13 477–481 Occurrence Handle7531224 Occurrence Handle1:STN:280:DyaK2M7kslSgtA%3D%3D
JW Rak Croix BD St RS Kerbel (1995) ArticleTitleConsequences of angiogenesis for tumour progression, metastasis and cancer therapy. Anticancer Drugs 6 3–18 Occurrence Handle7538829 Occurrence Handle10.1097/00001813-199502000-00001 Occurrence Handle1:CAS:528:DyaK2MXktlGgtrY%3D
J Folkman E Merler C Abernathy (1970) ArticleTitleIsolation of a tumor factor responsible for neovascularisation. J Exp Med 133 275–288 Occurrence Handle10.1084/jem.133.2.275
N Weidner J Folkman (1996) Tumoral vascularity as a prognostic factor in cancer. VT DeVita S Hellman SA Rosenburg (Eds) Important advances in oncology. Lippincott-Raven Philadelphia 167–190
ML George AS Dzik-Jurasz AR Padhani et al. (2001) ArticleTitleNon-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer. Br J Surg 88 1628–1636 Occurrence Handle11736977 Occurrence Handle10.1046/j.0007-1323.2001.01947.x Occurrence Handle1:STN:280:DC%2BD3MnptlansQ%3D%3D
LD Buadu J Murakami S Murayama et al. (1996) ArticleTitleBreast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis. Radiology 200 639–649 Occurrence Handle8756909 Occurrence Handle1:STN:280:DyaK28zkslyhuw%3D%3D
R Matsubayashi Y Matsuo G Edakuni et al. (2000) ArticleTitleBreast masses with peripheral rim enhancement on dynamic contrast-enhanced MR images: correlation of MR findings with histologic features and expression of growth factors. Radiology 217 841–848 Occurrence Handle11110952 Occurrence Handle1:STN:280:DC%2BD3M%2FotVOmtA%3D%3D
C Peters M Medl M Mirau et al. (1998) ArticleTitleColor-coded and spectral doppler flow in breast carcinomas-relationship with the tumor microvasculature. Breast Cancer Res Treat 47 83–89 Occurrence Handle10.1023/A:1005992916193
SM Galbraith MA Lodge NJ Taylor et al. (2002) ArticleTitleReproducibility of dynamic contrast-enhanced MRI in human muscles and tumours: comparison of quantitative and semi-quantitative analysis. NMR Biomed 15 132–142 Occurrence Handle11870909 Occurrence Handle10.1002/nbm.731
RD Johnson KR Geisinger (1996) ArticleTitleColorectal adenocarcinoma: staging and histopathology. Semin Roentgenol 31 94–102 Occurrence Handle8848736 Occurrence Handle10.1016/S0037-198X(96)80003-4 Occurrence Handle1:STN:280:DyaK283nt1SrtQ%3D%3D
PB Vermeulen G Gasparini SB Fox et al. (1996) ArticleTitleQuantification of angiogenesis in solid human tumors: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 32 2474–2484 Occurrence Handle10.1016/S0959-8049(96)00379-6
SA Abdalla F Behzad S Bsharah et al. (1999) ArticleTitlePrognostic relevance of microvessel density in colorectal tumors. Oncol Rep 6 839–842 Occurrence Handle10373667 Occurrence Handle1:STN:280:DyaK1MzgslKgsg%3D%3D
HJ Choi MS Hyun GJ Jung et al. (1998) ArticleTitleTumor angiogenesis as a prognostic predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence. Oncology 55 575–581 Occurrence Handle9778626 Occurrence Handle10.1159/000011915 Occurrence Handle1:STN:280:DyaK1cvltlGnsw%3D%3D
Y Takebayashi S Aklyama K Yamada et al. (1996) ArticleTitleAngiogenesis as unfavorable prognostic factor in human colorectal carcinoma. Cancer 78 226–231 Occurrence Handle8673996 Occurrence Handle10.1002/(SICI)1097-0142(19960715)78:2<226::AID-CNCR6>3.0.CO;2-J Occurrence Handle1:STN:280:DyaK283osVartQ%3D%3D
PB Vermeulen GG Van den Eynden P Huget et al. (1999) ArticleTitleProspective study of intatumoral microvessel density, p53 expression and survival in colorectal cancer. Br J Cancer 79 316–322 Occurrence Handle9888475 Occurrence Handle10.1038/sj.bjc.6690051 Occurrence Handle1:STN:280:DyaK1M7gtlGmsg%3D%3D
R Erlemann MF Reiser PE Peters et al. (1989) ArticleTitleMusculoskeleteal neoplasms: static and dynamic Gd-DTPA-enhanced MR imaging. Radiology 171 767–763 Occurrence Handle2717749 Occurrence Handle1:STN:280:DyaL1M3ktFaiug%3D%3D
R Gilles JM Guinebretiere LG Shapeero et al. (1993) ArticleTitleAssesment of breast cancer recurrence with contrast-enhanced subtraction MR-imaging: preliminary results in 26 patients. Radiology 188 473–478 Occurrence Handle8327700 Occurrence Handle1:STN:280:DyaK3szhslyrtg%3D%3D
M Müller-Schimpfle G Brix G Layer et al. (1993) ArticleTitleRecurrent rectal cancer: diagnosis with dynamic MR imaging. Radiology 189 881–889 Occurrence Handle8234720
C Frouge JM Guinebretiere G Contesso RD Paola M Blery (1994) ArticleTitleCorrelation between contrast enhancement in dynamic magnetic resonance imaging of the breast and tumor angiogenesis. Invest Radiol 29 1043–1049 Occurrence Handle7536719 Occurrence Handle10.1097/00004424-199412000-00006 Occurrence Handle1:STN:280:DyaK2M3jvVWjsw%3D%3D
CA Hulka BL Simith DC Sgroi et al. (1997) ArticleTitleDynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis. Radiology 205 837–842 Occurrence Handle9393545 Occurrence Handle1:STN:280:DyaK1c%2FlsFalsQ%3D%3D
K Axelsson BM Ljung DH Moore et al. (1995) ArticleTitleTumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. J Natl Cancer Inst 87 997–1008 Occurrence Handle7543156 Occurrence Handle10.1093/jnci/87.13.997 Occurrence Handle1:STN:280:DyaK2Mzls1ansQ%3D%3D
J Gribel NA Mayr A DeVries et al. (1997) ArticleTitleAssessment of tumor microcirculation: a new role of dynamic contrast MR imaging. J Magn Reson Imaging 7 111–119 Occurrence Handle10.1002/jmri.1880070115
HW Bruckner J Pitrelli M Merrick (2000) ArticleTitleAdenocarcinoma of the colon and rectum. Cancer Med 5 1472–1520
P Tofts G Brix D Buckley et al. (1999) ArticleTitleEstimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10 223–232 Occurrence Handle10508281 Occurrence Handle10.1002/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S Occurrence Handle1:STN:280:DyaK1Mvjsl2jtw%3D%3D
H Hawighorst M Libicher MV Knopp et al. (1999) ArticleTitleEvaluation of angiogenesis and perfusion of bone marrow lesions: role of semiquantitative and quantitative dynamic MRI. J Magn Reson Imaging 10 286–294 Occurrence Handle10508288 Occurrence Handle10.1002/(SICI)1522-2586(199909)10:3<286::AID-JMRI9>3.0.CO;2-N Occurrence Handle1:STN:280:DyaK1Mvjsl2isA%3D%3D
V Bonnerot A Charpentier F Frouin et al. (1992) ArticleTitleFactor analysis of dynamic magnetic resonance imaging in predicting the response of osteosarcoma to chemotherapy. Invest Radiol 27 847–855 Occurrence Handle1399442 Occurrence Handle10.1097/00004424-199210000-00016 Occurrence Handle1:STN:280:DyaK3s%2FhsVOmtA%3D%3D
GJ Parker J Suckling SF Tanner et al. (1997) ArticleTitleProbing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics. J Magn Reson Imaging 7 564–574 Occurrence Handle9170043 Occurrence Handle10.1002/jmri.1880070318 Occurrence Handle1:STN:280:DyaK2szhtlKnsA%3D%3D
SA Mirowitz WG Totty JK Lee (1992) ArticleTitleCharacterization of musculoskeletal masses using dynamic Gd-DTPA enhanced spin-echo MRI. J Comput Assist Tomogr 16 120–125 Occurrence Handle1729290 Occurrence Handle1:STN:280:DyaK387gsFGhtQ%3D%3D
JL Evelhoch (1999) ArticleTitleKey factors in the acquisition of contrast kinetic data for oncology. J Magn Reson Imaging 10 254–259 Occurrence Handle10508284 Occurrence Handle10.1002/(SICI)1522-2586(199909)10:3<254::AID-JMRI5>3.0.CO;2-9 Occurrence Handle1:STN:280:DyaK1Mvjsl2jug%3D%3D
Acknowledgments
Part of the subject group was used in another study presented as a scientific exhibit at the European Congress of Radiology (2002, Vienna).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tuncbilek, N., Karakas, H. & Altaner, S. Dynamic MRI in indirect estimation of microvessel density, histologic grade, and prognosis in colorectal adenocarcinomas . Abdom Imaging 29, 166–172 (2004). https://doi.org/10.1007/s00261-003-0090-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00261-003-0090-2