Skip to main content
SpringerLink
Log in

Single and tandem stents in sheep iliac arteries: Is there a difference in patency?

  • Laboratory Investigations
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose: To compare patency and neointima formation of single and tandem arterial stents.

Methods: In each of six sheep, two Memotherm nitinol stents (tandem stents) were inserted into the external iliac artery on one side and a single stent into the artery on the opposite side. The size of the iliac lumen was assessed in the proximal, middle, and distal segments of the stents by intravascular ultrasound (IVUS) before, immediately after, and 1 month after implantation when the sheep were killed. Neointimal thickness was determined in the proximal, middle, and distal segments of each stent by light microscopy.

Results: All stents remained patent. There was no significant difference in lumen and neointimal thickness between single and tandem stents. Cranial tandem stents showed a significantly wider lumen and smaller neointimal thickness than caudal tandem stents. In the proximal and distal segments, the lumen of the stents was significantly smaller and the neointimal thickness greater than in the middle segment; differences in neointimal thickness were significant only between the proximal and the middle segment.

Conclusion: In an experimental setting, tandem stents did not interfere with one another with regard to patency and neointima formation when compared with a single contralateral stent. Neointimal thickening after stent insertion seems to be inversely related to the original arterial diameter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Palmaz JC, Laborde JC, Rivera FJ, Encarnacion CE, Lutz JD, Moss JG (1992) Stenting of the iliac arteries with the Palmaz stent: Experience from a multicenter trial. Cardiovasc Intervent Radiol 15:291–297

    Article  PubMed  CAS  Google Scholar 

  2. Vorwerk D, Günther RW, Schürmann K, Wendt G (1995) Primary stent placement for chronic iliac artery occlusions: Follow-up results in 103 patients. Radiology 194:745–749

    PubMed  CAS  Google Scholar 

  3. Vorwerk D, Günther RW, Schürmann K, Wendt G (1996) Aortic and iliac stenoses: Follow-up results of stent placement after insufficient balloon angioplasty in 118 cases. Radiology 198:45–48

    PubMed  CAS  Google Scholar 

  4. Strecker EP, Hagen B, Liermann D, Schneider B, Wolf HR, Wambsganss J (1993) Iliac and femoropopliteal vascular occlusive disease treated with flexible tantalum stents. Cardiovasc Intervent Radiol 16:158–164

    Article  PubMed  CAS  Google Scholar 

  5. Orend KH, Heymer B, Scharrer Pamler R, Hahn J, Sunder-Plassmann L (1996) Histomorphological examination of endoluminal stent grafting in the descending aorta in a sheep model. Thorac Cardiovasc Surg 44:132–135

    Article  PubMed  CAS  Google Scholar 

  6. Henry M, Amor M, Porte J, Henry I, Ethevenot G, Ticoche O (1996) Initial experience with the Instent nitinol permanent and temporary stents. Radiology 201 [Suppl]:378

    Google Scholar 

  7. Lampmann LEH, Schoemaker MC, Hamming J, van Berge Hennegouwen DP (1996) Initial results with the Memotherm stent in iliac occlusive disease. Cardiovasc Intervent Radiol 19 [Suppl 2]:S84

  8. Shaw JW (1996) Management of aorto-iliac occlusive disease with the Memotherm self-expanding nitinol stent. J Intervent Radiol 11:119–127

    Google Scholar 

  9. Pernès JM, Auguste MA, Hovasse D, Gignier P, Lasry B, Lasry JL (1995) Long iliac stenosis: Initial clinical experience with the Cragg endoluminal graft. Radiology 196:67–71

    PubMed  Google Scholar 

  10. Kavteladze Z, Korchok A, Ivanov V, Babunaschvili A, Dundua D, Kartachov D (1995) New nitinol Kavteladze stent. Cardiovasc Intervent Radiol 18 [Suppl 1]:S82

  11. Palmaz JC, Richter GM, Noeldge G, Schatz RA, Robinson PD, Gardiner GA, Becker GJ, McLean GK, Denny DF, Lammer J, Paolini RM, Rees CR, Alvarado R, Heiss HW, Root HD, Rogers W (1988) Intraluminal stents in atherosclerotic iliac artery stenosis: Preliminary report of a multicenter study. Radiology 168:727–731

    PubMed  CAS  Google Scholar 

  12. Strecker EP, Romaniuk P, Schneider B, Westphal M, Zeitler E, Wolf RD, Freudenberg N (1988) Perkutan Implantierbare, durch Ballon aufdehnbare Gefäßprothese. Dtsch Med Wochenschr 113:538–542

    Article  PubMed  CAS  Google Scholar 

  13. Sigwart U, Puel J, Mirkovitch V, Joffre F, Kappenberger L (1987) Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N Engl J Med 326:701–706

    Article  Google Scholar 

  14. Schürmann K, Vorwerk D, Uppenkamp R, Klosterhalfen B, Bücker A, Günther RW (1997) Iliac arteries: Plain and heparin-coated Dacron-covered stent-grafts compared with non-covered metal stents—an experimental study. Radiology 203:55–63

    PubMed  Google Scholar 

  15. Lampmann LEH, Reekers JA, Jacobs MJHM, van Berge Henegouwen DP, Gasthuis E (1995) Initial results with a new self-expandable vascular nitinol stent. Cardiovasc Intervent Radiol 18 [Suppl 1]:S81

  16. Schürmann K, Vorwerk D, Kulisch A, Stroehmer-Kulisch E, Biesterfeld S, Stopinski T, Günther RW (1996) Neointimal hyperplasia in low-profile nitinol stents, Palmaz stents, and Wallstents: A comparative experimental study. Cardiovasc Intervent Radiol 19:248–254

    Article  PubMed  Google Scholar 

  17. Shaffer JP (1986) Modified sequentially rejective multiple test procedures. J Am Stat Assoc 81:826–831

    Article  Google Scholar 

  18. Barth KH, Virmani R, Froelich J, Takeda T, Lossef SV, Newsome J, Jones R, Lindisch D (1996) Paired coomparison of vascular wall reactions to Palmaz stents, Strecker tantalum stents and Wallstents in canine iliac and femoral arteries. Circulation 93:2161–2169

    PubMed  CAS  Google Scholar 

  19. Vorwerk D, Redha F, Neuerburg J, Clerc C, Günther RW (1994) Neointima formation following arterial placement of self-expanding stents of different radial force: Experimental results. Cardiovasc Intervent Radiol 17:27–32

    Article  PubMed  CAS  Google Scholar 

  20. Newman VS, Berry JL, Routh WD, Ferrario CM, Dean RH (1996) Effects of vascular stent surface area and hemodynamics on intimal thickening. J Vasc Interv Radiol 7:387–393

    Article  PubMed  CAS  Google Scholar 

  21. Chuapetcharasopon C, Wright KC, Wallace S, Dobben RL, Gianturco C (1992) Treatment of experimentally induced atherosclerosis in swine iliac arteries: A comparison of self-expanding and balloon-expanded stents. Cardiovasc Intervent Radiol 15:143–150

    Article  PubMed  CAS  Google Scholar 

  22. Fontaine AB, Spigos DG, Eaton G, Dos Passos S, Christoforidis G, Khabiri H, Jung S (1994) Stent-induced intimal hyperplasia: Are there fundamental differences between flexible and rigid stent designs? J Vasc Interv Radiol 5:739–744

    Article  PubMed  CAS  Google Scholar 

  23. Schürmann K, Vorwerk D, Kulisch A, Stroehmer-Kulisch E, Biesterfeld S, Stopinski T, Guenther RW (1995) Experimental arterial stent placement: Comparison of a new nitinol stent and Wallstent. Invest Radiol 30:412–420

    Article  PubMed  Google Scholar 

  24. Palmaz JC (1988) Balloon-expandable intravascular stent. AJR 150:1263–1269

    PubMed  CAS  Google Scholar 

  25. Palmaz JC (1993) Intravascular stents: Tissue-stent interactions and design considerations. AJR 160:613–618

    PubMed  CAS  Google Scholar 

  26. Tominaga R, Kambic HE, Emoto H, Harasaki H, Sutton C, Hollman J (1992) Effects of design geometry of intravascular endoprostheses on stenosis rate in normal rabbits. Am Heart J 123:21–28

    Article  PubMed  CAS  Google Scholar 

  27. Bauters C, Meurice T, Hamon M, McFadden E, Lablanche J-M, Bertrand ME (1996) Mechanism and prevention of restenosis: From experimental models to clinical practice. Cardiovasc Res 31:835–846

    PubMed  CAS  Google Scholar 

  28. Kakuta T, Currier JW, Haudenschild CC, Ryan TJ, Faxon DP (1994) Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation 89:2809–2815

    PubMed  CAS  Google Scholar 

  29. Palmaz JC (1992) Intravascular stenting: From basic research to clinical application. Cardiovasc Intervent Radiol 15:279–284

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, University of Technology, Pauwelsstrasse 30, D-52057, Aachen, Germany

    Karl Schürmann, Dierk Vorwerk, Arno Bücker, Stefanie Grosskortenhaus & Rolf W. Günther

Authors
  1. Karl Schürmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dierk Vorwerk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arno Bücker
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stefanie Grosskortenhaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rolf W. Günther
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schürmann, K., Vorwerk, D., Bücker, A. et al. Single and tandem stents in sheep iliac arteries: Is there a difference in patency?. Cardiovasc Intervent Radiol 21, 411–418 (1998). https://doi.org/10.1007/s002709900289

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002709900289

Key words

Search

Navigation