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Effects of iodinated contrast media on blood and endothelium

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Abstract

The aim of the study was to assess the effects of iodinated contrast media on blood components and endothelium based on experimental and clinical studies and to produce clinically relevant guidelines for reducing thrombotic and hematologic complications following the intravascular use of contrast media. A report was drafted after review of the literature and discussions among the members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology. The final report was produced following discussion at the 12th European Symposium on Urogenital Radiology in Ljubljana, Slovenia (2005). Experimental data indicate that all iodinated contrast media produce an anticoagulant effect and that this effect is greater with ionic contrast media. Several of the in vitro and experimental in vivo studies on haematological effects of contrast media have not been confirmed by clinical studies. Low- or iso-osmolar contrast media should be used for diagnostic and interventional angiographic procedures, including phlebography. Meticulous angiographic technique is the most important factor for reducing the thrombotic complications associated with angiographic procedures. Drugs and interventional devices that decrease the risk of thromboembolic complications during interventional procedures minimize the importance of the effects of contrast media.

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Authors and Affiliations

  1. Division of Radiology, Centre for Surgical Sciences, Karolinska Institute/Huddinge University Hospital, Stockholm, Sweden

    Peter Aspelin

  2. Institute of Radiology, Ospedale di Cattinara, Trieste, Italy

    Fulvio Stacul

  3. Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark

    Henrik S. Thomsen

  4. Department of Diagnostic Imaging, Northern General Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, S5 7AU, UK

    Sameh K. Morcos

  5. Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands

    Aart J. van der Molen

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  1. Peter Aspelin
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Members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR)

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Correspondence to Henrik S. Thomsen.

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ESUR:www.esur.org.

Members of the Committee: H.S. Thomsen (Chairman, Denmark), S.K. Morcos (Secretary, UK), T. Almén (Sweden), P. Aspelin (Sweden), M.F. Bellin (France), H. Flaten (Amersham Health, Norway), J.M. Idée (Guerbet, France) J.Å. Jakobsen (Norway), A. Löwe (Schering, Germany), R. Oyen (Belgium), A. Spinazzi (Bracco, Italy), F. Stacul (Italy), A.J. van der Molen (The Netherlands), J.A.W. Webb (UK).

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Members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR)., Aspelin, P., Stacul, F. et al. Effects of iodinated contrast media on blood and endothelium. Eur Radiol 16, 1041–1049 (2006). https://doi.org/10.1007/s00330-005-0081-5

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