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Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability

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Abstract

Perfusion-weighted magnetic resonance (MR) imaging using contrast agents plays a key role in characterizing tumors of the brain. We have shown that double-echo perfusion-weighted MR imaging (DEPWI) is potentially useful in assessing brain tumors. Quantitative indices, such as tumor blood volume, are obtained using DEPWI, which allows correction of underestimation of tumor blood volume due to leakage of contrast agents from tumor vessels, in addition to simultaneous acquisition of tumor vessel permeability. This article describes basic concepts of DEPWI and demonstrates clinical applications in brain tumors.

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Acknowledgements

The authors wish to thank Yoshiyuki Ishimori, R.T., of the University of Fukui, Genji Asanuma, R.T., of Mie University, and Tsuyoshi Matsuda, R.T., of GE-Yokogawa Medical Systems for their technical support.

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui, 910-1193, Japan

    Hidemasa Uematsu

  2. Department of Radiology, Mie University School of Medicine, Mie, Japan

    Masayuki Maeda

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  1. Hidemasa Uematsu
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  2. Masayuki Maeda
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Correspondence to Hidemasa Uematsu.

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Uematsu, H., Maeda, M. Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability. Eur Radiol 16, 180–186 (2006). https://doi.org/10.1007/s00330-005-2807-9

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  • DOI: https://doi.org/10.1007/s00330-005-2807-9

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