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Diagnostic value of 3D contrast-enhanced magnetic resonance angiography in Takayasu’s arteritis—a comparative study with digital subtraction angiography

  • Magnetic Resonance
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Abstract

Objective

To assess the diagnostic value of 3D CEMRA in TA compared with DSA.

Methods

Twenty-two patients with clinically suspected TA based on 1990 ACR criteria for the classification of TA, were included in this study. There were 16 female and 6 male patients with ages ranging from 11 to 50 years (mean age 25 years). CEMRA and DSA were performed in all patients within 4 weeks of each other, for detection of stenosis, occlusion and aneurysm in the arch vessels, renal arteries and aortic segments.

Results

(1) TA was confirmed by CEMRA in all patients. (2) 147 arteries did not reveal any steno-occlusive lesion on CEMRA compared with 158 on DSA. (3) 75 stenoses, (excluding occlusions) were detected on CEMRA compared with DSA, which revealed 65 stenotic lesions, with sensitivity, specificity, PPV, NPV and DA for detection of a significant (>50%) stenotic lesion being 98.33%, 97.25%, 92.18%, 99.43% and 97.52% respectively. (4) Aneurysmal dilatation was detected in 13 arteries on CEMRA compared with 16 on DSA.

Conclusions

Diagnostic value of CEMRA is comparable to that of DSA with a very strong and statistically significant correlation between DSA and CEMRA in detection and grading of characteristic steno-occlusive lesions of TA.

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Acknowledgement

The authors wish to extend their sincere thanks to Mr Varun Arora, Research Consultant, MBA (Hons.), MARMA (UK), MEARMA (Brussels), for his help with data analysis and statistical calculations in preparing the manuscript.

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Authors and Affiliations

  1. Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow, 226014, UP, India

    Shobhit K. Garg, Suyash Mohan & Sunil Kumar

  2. Neuroradiology Division, Department of Radiology, University of Pennsylvania Health System, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    Suyash Mohan

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  1. Shobhit K. Garg
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Correspondence to Sunil Kumar.

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Garg, S.K., Mohan, S. & Kumar, S. Diagnostic value of 3D contrast-enhanced magnetic resonance angiography in Takayasu’s arteritis—a comparative study with digital subtraction angiography. Eur Radiol 21, 1658–1666 (2011). https://doi.org/10.1007/s00330-011-2090-x

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  • DOI: https://doi.org/10.1007/s00330-011-2090-x

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