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Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: in vivo–in vitro (ex vivo) correlation

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An Erratum to this article was published on 24 April 2002

Abstract.

Nonketotic hyperglycinemia (NKH) is an inborn error of amino acid metabolism caused by a defect in the glycine cleavage multienzyme complex resulting in high concentrations of glycine within the brain and spinal cord. Quantitative magnetic resonance spectroscopy (1H-MRS) allows measurement of absolute glycine concentrations within different parts of the brain in vivo. In addition, 1H-MRS may be useful in monitoring treatment of NKH and to differentiate this disease from other disorders of glycine metabolism.

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Authors and Affiliations

  1. Department of Neuroradiology and Magnetic Resonance, University Children's Hospital Zurich, Zurich, Switzerland, Switzerland

    T. Huisman, T. Thiel & E. Martin

  2. Department of Metabolism and Molecular Pediatrics, University Children's Hospital Zurich, Zurich, Switzerland, Switzerland

    B. Steinmann

  3. Division of Neonatology, Regional Hospital Aarau, Aarau, Switzerland, Switzerland

    G. Zeilinger

Authors
  1. T. Huisman
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  2. T. Thiel
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  3. B. Steinmann
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  4. G. Zeilinger
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  5. E. Martin
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Electronic Publication

An erratum to this article is available at http://dx.doi.org/10.1007/s00330-002-1497-9.

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Huisman, T., Thiel, T., Steinmann, B. et al. Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: in vivo–in vitro (ex vivo) correlation. Eur Radiol 12, 858–861 (2002). https://doi.org/10.1007/s003300101073

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  • DOI: https://doi.org/10.1007/s003300101073

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