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The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children

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Abstract

Purpose

This study examines the changing epidemiology of paediatric brain tumours over the past three decades (1980–2008) in a single institution, SickKids, Toronto, Canada.

Methods

We classified 1,866 surgical pathology cases of brain tumours in children under the age of 19 according to the World Health Organization 2007 consensus and analysed them by gender, histological tumour type, age distribution and decade.

Results

Males showed a slightly higher predominance with 56.8% of cases overall. The main histological tumour types were low-grade (I/II) astrocytomas (26.4%), medulloblastoma (10.6%), anaplastic astrocytoma/glioblastoma multiforme (7.1%) and ependymoma (7.0%). Over three decades, an increasing proportion of certain tumour types, including pilocytic astroctoma, atypical teratoma/rhabdoid tumours and neuronal/mixed neuronal-glial tumours was seen.

Conclusions

Our results are consistent with those published with similar methodologies in other countries. Any changes in the epidemiology of childhood central nervous system tumours over the past three decades may be attributed in part to changing classification systems, improved imaging technologies and developments in epilepsy surgery; however, continued surveillance remains important.

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Acknowledgements

This work was supported by a grant from the Canadian Institutes of Health Research, the Canadian Heart and Stroke Foundation, the Surgeon-Scientist Program at the University of Toronto, Brainchild, and the Wiley Fund at the Hospital for Sick Children.

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Authors and Affiliations

  1. Division of Neurosurgery, The Department of Surgery, The Hospital for Sick Children, The University of Toronto, Suite 1503, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8

    Zul Kaderali, Maria Lamberti-Pasculli & James T. Rutka

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  1. Zul Kaderali
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  2. Maria Lamberti-Pasculli
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  3. James T. Rutka
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Correspondence to James T. Rutka.

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Kaderali, Z., Lamberti-Pasculli, M. & Rutka, J.T. The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children. Childs Nerv Syst 25, 787–793 (2009). https://doi.org/10.1007/s00381-008-0771-9

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  • DOI: https://doi.org/10.1007/s00381-008-0771-9

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