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Updated physiology and pathophysiology of CSF circulation—the pulsatile vector theory

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Abstract

Introduction

Hydrocephalus is still a not well-understood diagnostic and a therapeutic dilemma because of the lack of sufficient and comprehensive model of cerebrospinal fluid circulation and pathological alterations.

Conclusions

Based on current studies, reviews, and knowledge of cerebrospinal fluid dynamics, brain water dynamics, intracranial pressure, and cerebral perfusion physiology, a new concept is deducted that can describe normal and pathological changes of cerebrospinal fluid circulation and pathophysiology of idiopathic intracranial hypertension.

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Authors and Affiliations

  1. Department of Neurosurgery, Pediatric Neurosurgery, University Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany

    M. Preuss, J. Meixensberger & M. Dengl

  2. Division of Neuroradiology, University Leipzig, Leipzig, Germany

    K.-T. Hoffmann & M. Reiss-Zimmermann

  3. Division of Pediatric Radiology, University Leipzig, Leipzig, Germany

    W. Hirsch

  4. Division of Neuropediatric, University Leipzig, Leipzig, Germany

    A. Merkenschlager

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  1. M. Preuss
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  2. K.-T. Hoffmann
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Preuss, M., Hoffmann, KT., Reiss-Zimmermann, M. et al. Updated physiology and pathophysiology of CSF circulation—the pulsatile vector theory. Childs Nerv Syst 29, 1811–1825 (2013). https://doi.org/10.1007/s00381-013-2219-0

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