Skip to main content
Log in

Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with loss of morphological but retained genetic key features during progression

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Al-Hussain TO, Dababo MA (2009) Posterior fossa tumor in a 2-year-old girl. Brain Pathol 19(2):343–346. doi:10.1111/j.1750-3639.2009.00279.x

    Article  PubMed  Google Scholar 

  2. Buccoliero AM, Castiglione F, Degl’Innocenti DR, Franchi A, Paglierani M, Sanzo M, Cetica V, Giunti L, Sardi I, Genitori L, Taddei GL (2010) Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. Neuropathology 30(1):84–91. doi:10.1111/j.1440-1789.2009.01040.x

    Article  PubMed  Google Scholar 

  3. Dunham C, Sugo E, Tobias V, Wills E, Perry A (2007) Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation. J Neurooncol 84(1):91–98. doi:10.1007/s11060-007-9346-y

    Article  PubMed  Google Scholar 

  4. Dunkel IJ, Boyett JM, Yates A, Rosenblum M, Garvin JH Jr, Bostrom BC, Goldman S, Sender LS, Gardner SL, Li H, Allen JC, Finlay JL (1998) High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children’s Cancer Group. J Clin Oncol 16(1):222–228

    PubMed  CAS  Google Scholar 

  5. Eberhart CG, Brat DJ, Cohen KJ, Burger PC (2000) Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 3(4):346–352

    Article  PubMed  CAS  Google Scholar 

  6. Ferri Niguez B, Martinez-Lage JF, Almagro MJ, Fuster JL, Serrano C, Torroba MA, Sola J (2010) Embryonal tumor with abundant neuropil and true rosettes (ETANTR): a new distinctive variety of pediatric PNET: a case-based update. Childs Nerv Syst 26(8):1003–1008. doi:10.1007/s00381-010-1179-x

    Article  PubMed  Google Scholar 

  7. Fuller C, Fouladi M, Gajjar A, Dalton J, Sanford RA, Helton KJ (2006) Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes. Am J Clin Pathol 126(2):277–283. doi:10.1309/TFBX-1LWQ-93MX-QBAW

    Article  PubMed  Google Scholar 

  8. Gessi M, Giangaspero F, Lauriola L, Gardiman M, Scheithauer BW, Halliday W, Hawkins C, Rosenblum MK, Burger PC, Eberhart CG (2009) Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 33(2):211–217. doi:10.1097/PAS.0b013e318186235b

    Article  PubMed  Google Scholar 

  9. Gessi M, Zur Muehlen A, Lauriola L, Gardiman MP, Giangaspero F, Pietsch T (2011) TP53, beta-Catenin and c-myc/N-myc status in embryonal tumours with ependymoblastic rosettes. Neuropathol Appl Neurobiol 37(4):406–413. doi:10.1111/j.1365-2990.2010.01151.x

    Article  PubMed  CAS  Google Scholar 

  10. Kobayashi C, Monforte-Munoz HL, Gerbing RB, Stram DO, Matthay KK, Lukens JN, Seeger RC, Shimada H (2005) Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis index. Cancer 103(1):174–180. doi:10.1002/cncr.20717

    Article  PubMed  Google Scholar 

  11. Koh CM, Gurel B, Sutcliffe S, Aryee MJ, Schultz D, Iwata T, Uemura M, Zeller KI, Anele U, Zheng Q, Hicks JL, Nelson WG, Dang CV, Yegnasubramanian S, De Marzo AM (2011) Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene. Am J Pathol 178(4):1824–1834. doi:10.1016/j.ajpath.2010.12.040

    Article  PubMed  CAS  Google Scholar 

  12. Kopp K, Huang S (2005) Perinucleolar compartment and transformation. J Cell Biochem 95(2):217–225. doi:10.1002/jcb.20403

    Article  PubMed  CAS  Google Scholar 

  13. Korshunov A, Remke M, Gessi M, Ryzhova M, Hielscher T, Witt H, Tobias V, Buccoliero AM, Sardi I, Gardiman MP, Bonnin J, Scheithauer B, Kulozik AE, Witt O, Mork S, von Deimling A, Wiestler OD, Giangaspero F, Rosenblum M, Pietsch T, Lichter P, Pfister SM (2010) Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol 120(2):253–260. doi:10.1007/s00401-010-0688-8

    Article  PubMed  Google Scholar 

  14. La Spina M, Pizzolitto S, Skrap M, Nocerino A, Russo G, Di Cataldo A, Perilongo G (2006) Embryonal tumor with abundant neuropil and true rosettes. A new entity or only variations of a parent neoplasms (PNETs)? This is the dilemma. J Neurooncol 78(3):317–320. doi:10.1007/s11060-005-9105-x

    Article  PubMed  CAS  Google Scholar 

  15. Lamont JM, McManamy CS, Pearson AD, Clifford SC, Ellison DW (2004) Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 10(16):5482–5493. doi:10.1158/1078-0432.CCR-03-072110/16/5482

    Article  PubMed  CAS  Google Scholar 

  16. Li M, Lee KF, Lu Y, Clarke I, Shih D, Eberhart C, Collins VP, Van Meter T, Picard D, Zhou L, Boutros PC, Modena P, Liang ML, Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Lau CC, Taylor MD, Gajjar A, Dirks PB, Hawkins CE, Huang A (2009) Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 16(6):533–546. doi:10.1016/j.ccr.2009.10.025

    Article  PubMed  CAS  Google Scholar 

  17. Louis DN, Ohgaki H, Wiestler D, Cavanee WK (eds) (2007) WHO Classification of Tumours of the Central Nervous System, vol 4th Edition. IARC Press, Lyon

    Google Scholar 

  18. Manjila S, Ray A, Hu Y, Cai DX, Cohen ML, Cohen AR (2011) Embryonal tumors with abundant neuropil and true rosettes: 2 illustrative cases and a review of the literature. Neurosurg Focus 30(1):E2. doi:10.3171/2010.10.FOCUS10226

    Article  PubMed  Google Scholar 

  19. Pfister S, Remke M, Castoldi M, Bai AH, Muckenthaler MU, Kulozik A, von Deimling A, Pscherer A, Lichter P, Korshunov A (2009) Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 117(4):457–464. doi:10.1007/s00401-008-0467-y

    Article  PubMed  CAS  Google Scholar 

  20. Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J (2005) Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 352(10):978–986. doi:352/10/978[pii]10.1056/NEJMoa042176

    Article  PubMed  CAS  Google Scholar 

  21. Smetana K, Karban J, Trneny M (2010) To the nucleolar bodies (nucleoli) in cells of the lymphocytic lineage in patients suffering from B—chronic lymphocytic leukemia. Neoplasma 57(6):495–500

    Article  PubMed  CAS  Google Scholar 

  22. Tornoczky T, Semjen D, Shimada H, Ambros IM (2007) Pathology of peripheral neuroblastic tumors: significance of prominent nucleoli in undifferentiated/poorly differentiated neuroblastoma. Pathol Oncol Res 13(4):269–275. doi:PAOR.2007.13.4.0269

    Article  PubMed  Google Scholar 

  23. Wang Y, Chu SG, Xiong J, Cheng HX, Chen H, Yao XH (2011) Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with a focal amplification at chromosome 19q13.42 locus: further evidence of two new instances in China. Neuropathology. doi:10.1111/j.1440-1789.2011.01215.x

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christine Haberler.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Woehrer, A., Slavc, I., Peyrl, A. et al. Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with loss of morphological but retained genetic key features during progression. Acta Neuropathol 122, 787–790 (2011). https://doi.org/10.1007/s00401-011-0903-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-011-0903-2

Keywords

Navigation