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In vivo visualization of endolyphatic hydrops in patients with Meniere’s disease: correlation with audiovestibular function

  • Otology
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Abstract

Our objective is to determine whether the degree of endolymphatic hydrops as it is detected in vivo in patients with definite Meniere’s disease correlates with audiovestibular function. In this prospective study, 37 patients with definite Meniere’s disease according to AAO-HNS criteria were included. Intratympanic contrast enhanced temporal bone MRI was performed using a 3D FLAIR protocol. The degree of endolymphatic hydrops in the cochlea and the vestibulum was graded on a Likert scale (0–3). The degree of hydrops was then analyzed with respect to its correlation with audiometric hearing levels, electrocochleographic SP/AP ratios, interaural amplitude ratios of vestibular evoked myogenic potentials and degree of horizontal semicircular canal paresis on caloric irrigation. There was a significant correlation between the degree of hydrops on the one hand and the averaged hearing level at 0.25–1 and 0.5–3 kHz and the vestibular evoked myogenic potential interaural amplitude ratio on the other hand. A trend toward a correlation was noticed between the hydrops and the caloric response, no correlation was noticed between the hydrops and the SP/AP ratio. The degree of endolymphatic hydrops correlates with a progressive loss of auditory and sacculus function in patients with Meniere`s disease.

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Acknowledgments

This project was supported by funds from the German Federal Ministry of Education and Research under the Grant code 01 EO 0901. The authors bear full responsibility for the content of this publication.

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Authors and Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, Grosshadern Medical Centre, University of Munich, Marchioninistr. 15, 81377, Munich, Germany

    Robert Gürkov, Julia Louza & Eike Krause

  2. Integrated Centre for Balance Disorder, IFB-LMU, München, Germany

    Robert Gürkov, Michael Strupp & Eike Krause

  3. Department of Radiology, Grosshadern Medical Centre, University of Munich, 81377, Munich, Germany

    Wilhem Flatz

  4. Department of Neurology, Grosshadern Medical Centre, University of Munich, 81377, Munich, Germany

    Michael Strupp

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  1. Robert Gürkov
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  2. Wilhem Flatz
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  3. Julia Louza
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  4. Michael Strupp
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  5. Eike Krause
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Correspondence to Robert Gürkov.

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Gürkov, R., Flatz, W., Louza, J. et al. In vivo visualization of endolyphatic hydrops in patients with Meniere’s disease: correlation with audiovestibular function. Eur Arch Otorhinolaryngol 268, 1743–1748 (2011). https://doi.org/10.1007/s00405-011-1573-3

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  • DOI: https://doi.org/10.1007/s00405-011-1573-3

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