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Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Clinical observations show that two subtypes of sinonasal malignant melanoma exist: uni- and multilocular melanoma. The aim of this retrospective study was to determine the prevalence and outcome of multilocular sinonasal malignant melanoma. All patients with sinonasal malignant melanoma treated at our institution between 1992 and 2011 were included. Survival and recurrence data were analyzed related to the distribution pattern of the tumors and other factors. Twenty-five patients were identified and included in the analysis. Seven patients (28 %) suffered from multilocular, the remaining 18 patients (72 %) from unilocular sinonasal malignant melanoma. The first group showed a significantly worse disease-free survival, whereas disease-specific and overall survival did not differ between the two subtypes. Multilocular sinonasal malignant melanoma is associated with an unfavorable disease-free survival compared to its unilocular counterpart.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Zurich University Hospital, Frauenklinikstrasse 24, 8091, Zurich, Switzerland

    O. Stanimirov Rossi, Domenic Vital, M. B. Soyka, T. N. Roth, G. F. Huber & D. Holzmann

Authors
  1. O. Stanimirov Rossi
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  2. Domenic Vital
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  3. M. B. Soyka
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  4. T. N. Roth
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  5. G. F. Huber
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  6. D. Holzmann
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Corresponding author

Correspondence to Domenic Vital.

Additional information

O. Stanimirov Rossi and D. Vital contributed equally to this study.

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Stanimirov Rossi, O., Vital, D., Soyka, M.B. et al. Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?. Eur Arch Otorhinolaryngol 272, 123–129 (2015). https://doi.org/10.1007/s00405-014-3098-z

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  • DOI: https://doi.org/10.1007/s00405-014-3098-z

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