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Metabolic syndrome components and sudden sensorineural hearing loss: a case–control study

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

Cardiovascular risk factors, including metabolic syndrome (MetS) components, were reported as possible risk factors of sudden sensorineural hearing loss (SSNHL). The objective of this study was to evaluate the relationship between MetS (and its components) and SSNHL.

Methods

Eighty-one SSNHL patients and 243 sex-, aged-matched controls participated from January 2018 to July 2019. The participants included 176 (54.3%) men and 148 (45.7%) women. The correlation between Mets components, total cholesterol, low-density lipoprotein-cholesterol, and the onset of SSNHL was analyzed using used multivariate conditional logistic regression analysis.

Results

A total 12 patients (14.8%) with SSNHL and 27 subjects (11.1%) in control group had MetS (p > 0.05). The rate of low levels of high-density lipoprotein-cholesterol (HDL-C), hypertriglyceridemia, and hypertension was significantly higher in the SSNHL group than those in the control group (p < 0.05). A trend of odds SSNHL was observed with increasing the number of MetS components (p < 0.001). The multivariable analysis revealed that the rate of hypertriglyceridemia and low HDL-C concentration was significantly higher in the SSNHL groups compared to the controls.

Conclusions

Hypertriglyceridemia and low levels of HDL-C may be important factors in the pathogenesis of SSNHL, and should be assessed during the investigation of patients with this condition.

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Acknowledgements

The authors would like to thank the volunteers who participated in this research.

Funding

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Otorhinolaryngology Research Center, Department of Otolaryngology, School of Medicine, Guilan University of Medical Sciences, Rasht, Guilan, Iran

    Mir Mohammad Jalali & Mahsa Nasimidoust Azgomi

Authors
  1. Mir Mohammad Jalali
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  2. Mahsa Nasimidoust Azgomi
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by MMJ and MN. The first draft of the manuscript was written by MJ and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Mir Mohammad Jalali.

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The authors declare that they have no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Guilan University of Medical Sciences, IR.GUMS.REC.1397.269) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Jalali, M.M., Nasimidoust Azgomi, M. Metabolic syndrome components and sudden sensorineural hearing loss: a case–control study. Eur Arch Otorhinolaryngol 277, 1023–1029 (2020). https://doi.org/10.1007/s00405-020-05808-z

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  • DOI: https://doi.org/10.1007/s00405-020-05808-z

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