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Endolymphatic space size in patients with vestibular migraine and Ménière’s disease

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Abstract

Ménière’s disease (MD) is characterized by episodic vertigo, fluctuating hearing loss and tinnitus. Vestibular migraine (VM) is a relatively new disorder that is characterized by episodic vertigo or dizziness, coexisting migraine and absence of hearing loss. It is occasionally difficult to distinguish between VM and vestibular MD with headache. Because endolymphatic hydrops (EH) is a characteristic sign of MD, we attempted to evaluate endolymphatic space size in both diseases. Endolymphatic space size in the vestibule and the cochlea was evaluated in seven patients with VM and in seven age- and sex-matched patients with vestibular MD. For visualization of the endolymphatic space, 3T magnetic resonance imaging was taken 4 h after intravenous injection of gadolinium contrast agents using three-dimensional fluid-attenuated inversion recovery and HYbriD of reversed image of positive endolymph signal and native image of positive perilymph signal techniques. In the vestibule of VM patients, EH was not observed, with the exception of two patients with unilateral or bilateral EH. In contrast, in the vestibule of patients with vestibular MD, all patients had significant EH, bilaterally or unilaterally. These results indicate that endolymphatic space size is significantly different between patients with VM and vestibular MD.

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Acknowledgments

This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology in Japan (Kiban B-25293263, Kiban C-25462634 and Yong Scientists B 25861548).

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standard

All human studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. The research protocol was reviewed and approved by the institutional review board at Nagoya University Hospital.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-ku, Nagoya, 466-8550, Japan

    Takafumi Nakada, Tadao Yoshida, Kenji Suga, Masahiro Kato, Hironao Otake, Ken Kato, Masaaki Teranishi, Michihiko Sone & Tsutomu Nakashima

  2. Department of Sleep Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Hironao Otake

  3. Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan

    Saiko Sugiura & Tsutomu Nakashima

  4. Department of Otorhinolaryngology, Kamiida Daiich General Hospital, Nagoya, Japan

    Kayao Kuno

  5. Department of Otolaryngology, University of Tampere, Tampere, Finland

    Ilmari Pyykkö

  6. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Shinji Naganawa

  7. Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Hirohisa Watanabe & Gen Sobue

  8. Brain and Mind Research Center, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Hirohisa Watanabe & Gen Sobue

Authors
  1. Takafumi Nakada
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  2. Tadao Yoshida
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  3. Kenji Suga
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  4. Masahiro Kato
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  6. Ken Kato
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  7. Masaaki Teranishi
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  8. Michihiko Sone
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  9. Saiko Sugiura
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  10. Kayao Kuno
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  11. Ilmari Pyykkö
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  12. Shinji Naganawa
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  13. Hirohisa Watanabe
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  14. Gen Sobue
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  15. Tsutomu Nakashima
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Corresponding author

Correspondence to Takafumi Nakada.

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Nakada, T., Yoshida, T., Suga, K. et al. Endolymphatic space size in patients with vestibular migraine and Ménière’s disease. J Neurol 261, 2079–2084 (2014). https://doi.org/10.1007/s00415-014-7458-9

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  • DOI: https://doi.org/10.1007/s00415-014-7458-9

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