Summary
We report a study of a 22-year-old woman with a plasma-cell granuloma (PCG), a rare intracranial lesion characterized by a non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. She presented after a generalized seizure and CT-scan and magnetic resonance images demonstrated a left temporo-basal tumour mass involving both the meningeal layers and the brain parenchyma. Histopathological examination of a biopsy led to the diagnosis of a typical PCG. After a short course of steroid administration, the clinical and radiological features improved and complete regression of the lesion was shown after one year and persisted at four-year follow-up. This dramatic regression of an intracranial PCG shows that neither surgical removal nor radiation therapy is required to treat a broad skull base PCG.
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Roche, PH., Figarella-Branger, D. & Pellet, W. Mixed meningeal and brain plasma-cell granuloma: an example of an unusual evolution. Acta Neurochir 146, 69–72 (2004). https://doi.org/10.1007/s00701-003-0153-8
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DOI: https://doi.org/10.1007/s00701-003-0153-8