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MR imaging characteristics of oligodendroglial tumors with assessment of 1p/19q deletion status

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Abstract

Purpose

Patients with oligodendrogliomas with allelic loss of chromosomal arm 1p and 19q have been shown, especially with anaplastic oligodendrogliomas, to have both a better initial and long-term response to chemotherapy as well as an improved overall survival. Effective treatment of patients with brain tumors requires accurate diagnostic techniques. MR imaging can be used to help differentiate between low- and high-grade tumors. We hypothesize that certain MR imaging characteristics can be used to differentiate between patients with and without 1p and 19q deletion.

Methods

Using the clinical database at the University of Virginia Neuro-Oncology Center, we identified adult patients with grade II and III oligodendroglial tumors who underwent treatment from 2002 to 2007. Age at diagnosis, gender, tumor grade, chromosomal deletion status, duration of follow-up, and MR imaging characteristics were analyzed; the latter was read by a blinded neuroradiologist.

Results

One hundred and four patients met the inclusion criteria. Of these patients, 44 manifested 1p/19q co-deletion and 60 patients lacked this deletion. The greatest cross-sectional area (mean) of the tumor measured 23.4 cm2 for patients with the co-deletion and 31.7 cm2 for patients with intact alleles (p = 0.008). In addition, inner table thinning was noted directly adjacent to seven tumors with intact 1p and 19q alleles and in no tumors with the 1p/19q co-deletion (p = 0.020). Amongst patients with pure oligodendrogliomas, those with 1p/19q co-deletion had tumors more often confined to a single lobe as compared with those patients without the co-deletion (p = 0.023). Finally, tumors with intact alleles were more often found in the temporal lobe (45.0%) as compared with co-deleted tumors (22.7%) (p = 0.011).

Conclusion

MR imaging is a valuable imaging modality for differentiating between oligodendrogliomas with or without the 1p/19q deletion. While imaging will never replace definitive tissue diagnosis, imaging characteristics such as tumor size, location, and overlying skull thinning can assist clinicians in assessing patients with oligodendroglial tumors prior to surgical or medical intervention.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of Virginia, P. O. Box 800212, Health Sciences Center, Charlottesville, VA, 22908, USA

    Jonathan H. Sherman, Nader Pouratian, Robert M. Starke, Mark E. Shaffrey & David Schiff

  2. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Daniel M. Prevedello

  3. Department of Radiology, University of Utah, Salt Lake City, UT, USA

    Lubdha Shah

  4. Department of Radiology, University of Virginia, Charlottesville, VA, USA

    Prashant Raghavan

  5. Department of Pathology, Division of Neuropathology, University of Virginia, Charlottesville, VA, USA

    M. Beatriz S. Lopes

  6. Department of Neurology, University of Virginia, Charlottesville, VA, USA

    David Schiff

  7. Department of Medicine, University of Virginia, Charlottesville, VA, USA

    David Schiff

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  1. Jonathan H. Sherman
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Correspondence to Jonathan H. Sherman.

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Sherman, J.H., Prevedello, D.M., Shah, L. et al. MR imaging characteristics of oligodendroglial tumors with assessment of 1p/19q deletion status. Acta Neurochir 152, 1827–1834 (2010). https://doi.org/10.1007/s00701-010-0743-1

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  • DOI: https://doi.org/10.1007/s00701-010-0743-1

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