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Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease detected on 3D constructive interference in steady-state MR image: is arterial constrictive remodeling a major pathogenesis?

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Abstract

Background

To obtain information on affected vessels in moyamoya disease (MMD), we analyzed the vascular morphological characteristics of MMD using three-dimensional (3D) constructive interference in steady-state (CISS) magnetic resonance imaging (MRI).

Methods

The population of this 3D-CISS MRI study consisted of 51 patients with MMD: 16 patients with atherosclerotic middle cerebral artery (MCA) stenosis or occlusion, 42 MRI control patients, and 28 control digital subtraction angiography (DSA) patients. We measured the outer diameters of the terminal portion of the internal carotid artery (ICA) and the proximal portion of the MCA (M1 portion). We evaluated the inner diameter as the relative value (%) obtained from magnified DSA images and analyzed these data.

Results

The outer diameters of the ICA and M1 portions were significantly smaller in the MMD group than in the other two groups, while the M1 outer diameter of the atherosclerosis group was not significantly different compared to the control (ICA: MMD, 2.61 ± 0.46 mm vs. control, 4.04 ± 0.50 mm and M1: MMD, 1.92 ± 0.43 mm vs. control, 3.34 ± 0.54 mm vs. atherosclerosis, 3.45 ± 0.56 mm). Furthermore, in MMD patients, the outer diameter was unrelated to the progression of the luminal stenosis grade estimated by DSA.

Conclusions

This is the first report that the outer diameters of both the ICA and M1 decrease in MMD patients. Our findings suggest that the vascular constrictive changes of the affected arteries are an important phenomenon reflecting MMD pathology.

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Conflicts of interest

None.

Grant support

This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Sports, Science and Culture of Japan.

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Authors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Kumamoto University, Kumamoto, Japan

    Yasuyuki Kaku, Yuki Ohmori, Takayuki Kawano, Yutaka Kai & Jun-ichi Kuratsu

  2. Department of Diagnostic Radiology, School of Medicine, Kumamoto University, Kumamoto, Japan

    Hirofumi Fukuoka, Toshinori Hirai & Yasuyuki Yamashita

  3. Department of Neurosurgery, School of Medicine, Kurume University, 67 Asahimachi, Kurume, 830-0011, Japan

    Motohiro Morioka

Authors
  1. Yasuyuki Kaku
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  2. Motohiro Morioka
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  3. Yuki Ohmori
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  4. Takayuki Kawano
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  5. Yutaka Kai
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  6. Hirofumi Fukuoka
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  7. Toshinori Hirai
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  9. Jun-ichi Kuratsu
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Corresponding author

Correspondence to Motohiro Morioka.

Additional information

Yasuyuki Kaku and Motohiro Morioka contributed equally to this work.

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Kaku, Y., Morioka, M., Ohmori, Y. et al. Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease detected on 3D constructive interference in steady-state MR image: is arterial constrictive remodeling a major pathogenesis?. Acta Neurochir 154, 2151–2157 (2012). https://doi.org/10.1007/s00701-012-1472-4

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  • DOI: https://doi.org/10.1007/s00701-012-1472-4

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