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Grid-free interactive and automated data processing for MR chemical shift imaging data

  • Research Article
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Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

An Erratum to this article was published on 01 April 2010

Abstract

Purpose

Today’s available chemical shift imaging (CSI) analysis tools are based on Fourier transform of the entire data set prior to interactive display. This strategy is associated with limitations particularly when arbitrary voxel positions within a 3D spatial volume are needed by the user. In this work, we propose and demonstrate a processing-resource-efficient alternative strategy for both interactive and automated CSI data processing up to three spatial dimensions.

Methods

This approach uses real-time voxel-shift by first-order phase manipulation as a basis and therefore allows grid-free voxel positioning within the 3D volume. The corresponding spectrum is extracted from the 4D data (3D spatial/1D spectral) at each time a voxel position is selected. The spatial response function and hence the exact voxel size and shape are calculated in parallel including the same processing parameters. Using this mechanism sequentially along with AMARES time-domain modeling, we also implemented automated quantitative and B 0-insensitive metabolite mapping.

Results

Metabolite maps of N-acetyl aspartate, choline and creatine were generated using 1H-CSI data from the brain of healthy volunteers and patients with tumor and epilepsy. 31P-3D-CSI of the heart of a healthy volunteer is also shown.

Conclusion

The calculated metabolite maps demonstrate good stability and accuracy of the algorithm in all situations tested. The suggested algorithm constitutes therefore an attractive alternative to existing CSI processing strategies.

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Authors and Affiliations

  1. Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS No 6612, Faculté de Médecine de Marseille, Université de la Méditerranée, 27 Bd Jean Moulin, 13385, Marseille Cedex 5, France

    Yann Le Fur, François Nicoli, Maxime Guye, Sylviane Confort-Gouny, Patrick J. Cozzone & Frank Kober

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  1. Yann Le Fur
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  2. François Nicoli
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  3. Maxime Guye
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  4. Sylviane Confort-Gouny
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  5. Patrick J. Cozzone
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  6. Frank Kober
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Corresponding authors

Correspondence to Yann Le Fur or Frank Kober.

Additional information

Grant Support: This work was sponsored by Centre National de la Recherche Scientifique (CNRS UMR No 6612), Université de la Méditerranée and Institut Universitaire de France.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10334-010-0210-2

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Le Fur, Y., Nicoli, F., Guye, M. et al. Grid-free interactive and automated data processing for MR chemical shift imaging data. Magn Reson Mater Phy 23, 23–30 (2010). https://doi.org/10.1007/s10334-009-0186-y

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  • DOI: https://doi.org/10.1007/s10334-009-0186-y

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