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Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL

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Abstract

Objective

Dynamic susceptibility contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level of DSC-MRI CBF.

Materials and methods

Twenty healthy volunteers were scanned in a test–retest approach. Independent CBV measurements for calibration were accomplished using a T1-based contrast agent steady-state method (referred to as Bookend), as well as a blood-nulling vascular space occupancy (VASO) approach. Calibrated DSC-MRI was compared with pseudo-continuous arterial spin labeling (pCASL).

Results

For segmented grey matter (GM) regions of interests (ROIs), pCASL-based CBF was 63 ± 11 ml/(min 100 g) (mean ± SD). Nominal CBF from non-calibrated DSC-MRI was 277 ± 61 ml/(min 100 g), while calibrations resulted in 56 ± 23 ml/(min 100 g) (Bookend) and 52 ± 16 ml/(min 100 g) (VASO). Calibration tended to eliminate the overestimation, although the repeatability was generally moderate and the correlation between calibrated DSC-MRI and pCASL was low (r < 0.25). However, using GM instead of WM ROIs for extraction of CFs resulted in improved repeatability.

Conclusion

Both calibration approaches provided reasonable absolute levels of GM CBF, although the calibration methods suffered from low signal-to-noise ratio, resulting in weak repeatability and difficulties in showing high degrees of correlation with pCASL measurements.

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Acknowledgments

Thanks to Dr. Christian Stehning at Philips Research in Hamburg for providing the sequence for T1 measurements. This study was supported by the Swedish Research Council (Grant Nos. 13514 and 2010-4454).

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Authors and Affiliations

  1. Department of Medical Radiation Physics, Lund University, Lund University Hospital, 22185, Lund, Sweden

    Emelie Lindgren, Ronnie Wirestam, Karin Markenroth Bloch, André Ahlgren, Freddy Ståhlberg & Linda Knutsson

  2. Clinical Science, Philips Healthcare, Lund, Sweden

    Karin Markenroth Bloch

  3. C.J.Gorter Center for High Field MRI, Department of Radiology, LUMC, Leiden, The Netherlands

    Matthias J. P. van Osch

  4. Center for Medical Imaging and Physiology, Skåne University Hospital Lund, Lund, Sweden

    Danielle van Westen

  5. Department of Diagnostic Radiology, Lund University, Lund, Sweden

    Danielle van Westen & Freddy Ståhlberg

  6. Department of Clinical Sciences, Lund University, Lund, Sweden

    Yulia Surova

  7. Department of Neurology, Skåne University Hospital, Lund, Sweden

    Yulia Surova

  8. Lund University Bioimaging Center, Lund University, Lund, Sweden

    Freddy Ståhlberg

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  1. Emelie Lindgren
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Correspondence to Emelie Lindgren.

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Lindgren, E., Wirestam, R., Markenroth Bloch, K. et al. Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL. Magn Reson Mater Phy 27, 487–499 (2014). https://doi.org/10.1007/s10334-014-0431-x

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  • DOI: https://doi.org/10.1007/s10334-014-0431-x

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