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X-ray Velocimetry and Haemodynamic Forces Within a Stenosed Femoral Model at Physiological Flow Rates

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Abstract

High resolution in vivo velocity measurements within the cardiovascular system are essential for accurate calculation of vessel wall shear stress, a highly influential factor for the progression of arterial disease. Unfortunately, currently available techniques for in vivo imaging are unable to provide the temporal resolution required for velocity measurement at physiological flow rates. Advances in technology and improvements in imaging systems are allowing a relatively new technique, X-ray velocimetry, to become a viable tool for such measurements. This study investigates the haemodynamics of pulsatile blood flow in an optically opaque in vitro model at physiological flow rates using X-ray velocimetry. The in vitro model, an asymmetric stenosis, is designed as a 3:1 femoral artery with the diameter and flow rate replicating vasculature of a mouse. Velocity measurements are obtained over multiple cycles of the periodic flow at high temporal and spatial resolution (1 ms and 29 μm, respectively) allowing accurate measurement of the velocity gradients and calculation of the wall shear stress. This study clearly illustrates the capability of in vitro X-ray velocimetry, suggesting it as a possible measurement technique for future in vivo vascular wall shear stress measurement.

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Acknowledgments

The authors gratefully acknowledge the support of the Japan Synchrotron Radiation Research Institute (JASRI) (under Proposal No. SP2009B1910). The authors would like to thank Yoshio Suzuki, Akihisa Takeuchi and Kentaro Uesugi (SPring-8/JASRI) for their assistance with the experiments. Support from the Australian Research Council (Grant Nos. DP0877327, DP0987643) is also gratefully acknowledged.

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Authors and Affiliations

  1. Division of Biological Engineering, Monash University, Victoria, 3800, Australia

    R. Aidan Jamison, Stephen Dubsky, Kerry Hourigan & Andreas Fouras

  2. Department of Mechanical Engineering, Monash University, Victoria, 3800, Australia

    R. Aidan Jamison, Stephen Dubsky & Kerry Hourigan

  3. School of Physics, Monash University, Victoria, 3800, Australia

    Karen K. W. Siu

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  1. R. Aidan Jamison
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  2. Stephen Dubsky
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  5. Andreas Fouras
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Correspondence to Andreas Fouras.

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Associate Editor Konstantinos Konstantopoulos oversaw the review of this article.

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Jamison, R.A., Dubsky, S., Siu, K.K.W. et al. X-ray Velocimetry and Haemodynamic Forces Within a Stenosed Femoral Model at Physiological Flow Rates. Ann Biomed Eng 39, 1643–1653 (2011). https://doi.org/10.1007/s10439-011-0260-2

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  • DOI: https://doi.org/10.1007/s10439-011-0260-2

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