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pyNS: An Open-Source Framework for 0D Haemodynamic Modelling

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Abstract

A number of computational approaches have been proposed for the simulation of haemodynamics and vascular wall dynamics in complex vascular networks. Among them, 0D pulse wave propagation methods allow to efficiently model flow and pressure distributions and wall displacements throughout vascular networks at low computational costs. Although several techniques are documented in literature, the availability of open-source computational tools is still limited. We here present python Network Solver, a modular solver framework for 0D problems released under a BSD license as part of the archToolkit (http://archtk.github.com). As an application, we describe patient-specific models of the systemic circulation and detailed upper extremity for use in the prediction of maturation after surgical creation of vascular access for haemodialysis.

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Acknowledgments

The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7-ICT-2007-2: Project ARCH n. 224390). Partners of the ARCH Consortium are: IRCCS Mario Negri Institute, Bergamo (IT); Academisch Ziekenhuis Maastricht (NL); Philips Medical Systems, Eindhoven (NL); Philips Research, Eindhoven (NL); Esaote Europe BV, Maastricht (NL); Ghent University (BE); Sheffield University (UK); Lubljana Medical University (SL).

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Authors and Affiliations

  1. Orobix Srl, Bergamo, Italy

    Simone Manini & Luca Antiga

  2. Biomedical Engineering Department, IRCCS Mario Negri Institute for Pharmacological Research, Milan, Italy

    Andrea Remuzzi

  3. Industrial Engineering Department, University of Bergamo, Bergamo, Italy

    Lorenzo Botti & Andrea Remuzzi

Authors
  1. Simone Manini
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  2. Luca Antiga
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  3. Lorenzo Botti
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  4. Andrea Remuzzi
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Correspondence to Simone Manini.

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Associate Editor Diego Gallo oversaw the review of this article.

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Manini, S., Antiga, L., Botti, L. et al. pyNS: An Open-Source Framework for 0D Haemodynamic Modelling. Ann Biomed Eng 43, 1461–1473 (2015). https://doi.org/10.1007/s10439-014-1234-y

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  • DOI: https://doi.org/10.1007/s10439-014-1234-y

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