Abstract
It has been reported recently that oligodendroglial tumors arising in the insula rarely harbor co-deletions of chromosomes 1p and 19q, a molecular signature which is associated with a good prognosis and increased responsiveness to radiation and chemotherapy compared with tumors in which 1p and/or 19q is intact. In the context of this claim, we analyzed a series of insular oligodendroglial tumors in order to determine the frequency of 1p/19q co-deletion in tumors arising in this region. We identified 14 insular cases operated on after 2003 in which testing for losses of 1p and 19q was performed. Of these cases, co-deletion of 1p and 19q occurred in eight (57%). Four (50%) of eight oligodendrogliomas and four (67%) of six oligoastrocytomas demonstrated 1p/19q co-deletions. Seven of the eight tumors with co-deletion of 1p/19q were WHO grade II gliomas. There were no statistical differences between tumors with 1p/19q co-deletion compared to those with 1p and/or 19q intact in terms of age, preoperative KPS, presenting symptoms, left versus right lateralization, tumor location (purely insular versus extension into frontal or temporal lobe), preoperative tumor size. There was a preponderance of females in the co-deletion group, and a greater average extent of resection. In contradistinction to previous reports, loss of 1p/19q occurs commonly in insular oligodendroglial tumors. With respect to 1p/19q, insular gliomas do not appear to be distinct from gliomas arising elsewhere in the brain.
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Acknowledgements
The authors thank Stephanie Jenkins for her excellent assistance with the preparation of the manuscript. This work was supported by NIH/NCI grants R01 CA115729 and P50 CA127001, a grant from the National Brain Tumor Foundation, and by the Elias Family Fund for Brain Tumor Research, the Gene Pennebaker Brain Cancer Research Fund, and the Brian McCulloch Research Fund.
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Wu, A., Aldape, K. & Lang, F.F. High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors. J Neurooncol 99, 57–64 (2010). https://doi.org/10.1007/s11060-009-0100-5
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DOI: https://doi.org/10.1007/s11060-009-0100-5