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Effect of contrast leakage on the detection of abnormal brain tumor vasculature in high-grade glioma

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Abstract

Abnormal brain tumor vasculature has recently been highlighted by a dynamic susceptibility contrast (DSC) MRI processing technique. The technique uses independent component analysis (ICA) to separate arterial and venous perfusion. The overlap of the two, i.e. arterio-venous overlap or AVOL, preferentially occurs in brain tumors and predicts response to anti-angiogenic therapy. The effects of contrast agent leakage on the AVOL biomarker have yet to be established. DSC was acquired during two separate contrast boluses in ten patients undergoing clinical imaging for brain tumor diagnosis. Three components were modeled with ICA, which included the arterial and venous components. The percentage of each component as well as a third component were determined within contrast enhancing tumor and compared. AVOL within enhancing tumor was also compared between doses. The percentage of enhancing tumor classified as not arterial or venous and instead into a third component with contrast agent leakage apparent in the time-series was significantly greater for the first contrast dose compared to the second. The amount of AVOL detected within enhancing tumor was also significantly greater with the second dose compared to the first. Contrast leakage results in large signal variance classified as a separate component by the ICA algorithm. The use of a second dose mitigates the effect and allows measurement of AVOL within enhancement.

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Acknowledgments

Special thanks to the patients who chose to participate in this study. This work was funded by NIH/NCI R01CA082500, and Advancing a Healthier Wisconsin.

Conflict of interest

All authors report no conflict of interest.

Ethical standards

This research was performed in approval of our institutional review board.

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Authors and Affiliations

  1. Department of Radiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA

    Peter S. LaViolette, Mitchell K. Daun & Kathleen M. Schmainda

  2. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

    Eric S. Paulson

  3. Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA

    Kathleen M. Schmainda

Authors
  1. Peter S. LaViolette
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  2. Mitchell K. Daun
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  3. Eric S. Paulson
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  4. Kathleen M. Schmainda
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Corresponding author

Correspondence to Peter S. LaViolette.

Additional information

Peter S. LaViolette and Mitchell K. Daun contributed equally to this work.

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LaViolette, P.S., Daun, M.K., Paulson, E.S. et al. Effect of contrast leakage on the detection of abnormal brain tumor vasculature in high-grade glioma. J Neurooncol 116, 543–549 (2014). https://doi.org/10.1007/s11060-013-1318-9

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  • DOI: https://doi.org/10.1007/s11060-013-1318-9

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