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Differences between glioblastomas and primary central nervous system lymphomas in 1H-magnetic resonance spectroscopy

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Abstract

Purpose

The present study aimed to distinguish between glioblastomas and primary central nervous system lymphomas (PCNSLs) using 1H-magnetic resonance spectroscopy (MRS), especially glutamate (Glu)/creatine (Cr) and Glu/Glu+glutamine (Gln) ratios.

Materials and methods

A total of 46 patients (31 cases diagnosed with glioblastoma, 15 with PCNSL) were examined by in vivo single-voxel proton 1H-MRS with a 3-T MR imaging system. Differences in absolute concentration of Cr, choline/Cr, lipid (1.3 ppm)/Cr, Glu+Gln/Cr, Glu/Cr, and Glu/Glu+Gln ratios among groups were evaluated with Mann–Whitney U tests.

Results

PCNSLs [3.408 ± 1.194 (standard deviation)] showed significantly higher Glu/Cr ratios as compared to glioblastomas (2.220 ± 0.942; P = 0.003) [Glu/Cr cutoff ratio of 2.509 showed a sensitivity of 88 % (7/8) and a specificity of 92 % (22/24)], while glioblastomas (0.539 ± 0.098) showed significantly lower Glu/Glu+Gln ratios as compared to PCNSLs (0.728 ± 0.147; P < 0.001) [Glu/Glu+Gln cutoff ratio of 0.558 showed a sensitivity of 69 % (18/26) and a specificity of 100 % (13/13)]. And PCNSLs (1.101 ± 0.387) showed significantly higher Cho/Cr ratios as compared to glioblastomas (0.850 ± 0.465; P = 0.026).

Conclusion

Glu/Cr, Glu/Glu+Gln, and Cho/Cr ratios may be useful in distinguishing between glioblastomas and PCNSLs.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard and patient consent

We declare that all human and animal studies have been approved by Kanazawa University Graduate School of Medicine and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

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Authors and Affiliations

  1. Department of Radiology, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan

    Hiroyuki Aburano, Fumiaki Ueda, Osamu Matsui & Toshifumi Gabata

  2. Department of Radiology, Toyama City Hospital, Imaizumihokubu-nachi 2-1, Toyama, Toyama, 939-8511, Japan

    Yuichi Yoshie

  3. Department of Neurosurgery, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan

    Mitsutoshi Nakada & Yutaka Hayashi

Authors
  1. Hiroyuki Aburano
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  2. Fumiaki Ueda
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  3. Yuichi Yoshie
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  4. Osamu Matsui
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  5. Mitsutoshi Nakada
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  6. Yutaka Hayashi
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  7. Toshifumi Gabata
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Corresponding author

Correspondence to Hiroyuki Aburano.

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Aburano, H., Ueda, F., Yoshie, Y. et al. Differences between glioblastomas and primary central nervous system lymphomas in 1H-magnetic resonance spectroscopy. Jpn J Radiol 33, 392–403 (2015). https://doi.org/10.1007/s11604-015-0430-5

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  • DOI: https://doi.org/10.1007/s11604-015-0430-5

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