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Exposure to Cigarette Smoke and the Carotid Arteries Calcification Index in Patients with Essential Hypertension

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Abstract

The arteries calcification index is a quantitative, mathematically estimated parameter characterizing the total amount of calcium within atherosclerotic plaques in the walls of arteries. The objective is to determine a relationship between exposure to cigarette smoke and the carotid arteries calcification index in patients with essential hypertension. The tested group included 66 patients with essential hypertension: 19 active smokers (subgroup A), 20 non-smokers, environmentally exposed to cigarette smoke (subgroup B) and 27 persons without exposure to cigarette smoke (subgroup C). The tested group was subjected to computed tomography angiography of carotid arteries. Evaluation of the carotid arteries calcification indexes was conducted. The average value of the total calcification index of the carotid arteries (CAci) amounted to 368.28 ± 384.21. In subgroup A and B in relation to subgroup C, CAci was significantly higher. In summary, active and passive smoking in patients with essential hypertension may be associated with a higher calcification index of carotid arteries.

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References

  1. World Health Organization. (2015). WHO report on the global tobacco epidemic, 2015. Geneva: WHO.

    Google Scholar 

  2. Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, W. M., et al. (2012). European guidelines on cardiovascular disease prevention in clinical practice (version 2012): The fifth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). International Journal of Behavioral Medicine, 19(4), 403–488.

    Article  PubMed  Google Scholar 

  3. Gać, P., Poręba, M., Mazur, G., & Poręba, R. (2015). The aortic mechanical properties in patients with the essential hypertension environmentally exposed to cigaret smoke. Inhalation Toxicology, 27(13), 717–723.

    Article  PubMed  Google Scholar 

  4. Mainali, P., Pant, S., Rodriguez, A. P., Deshmukh, A., & Mehta, J. L. (2015). Tobacco and cardiovascular health. Cardiovascular Toxicology, 15(2), 107–116.

    Article  CAS  PubMed  Google Scholar 

  5. West, H. W., Juonala, M., Gall, S. L., Kähönen, M., Laitinen, T., Taittonen, L., et al. (2015). Exposure to parental smoking in childhood is associated with increased risk of carotid atherosclerotic plaque in adulthood: The cardiovascular risk in Young Finns study. Circulation, 131(14), 1239–1246.

    Article  CAS  PubMed  Google Scholar 

  6. Ibrahimi, P., Jashari, F., Nicoll, R., Bajraktari, G., Wester, P., & Henein, M. Y. (2013). Coronary and carotid atherosclerosis: How useful is the imaging? Atherosclerosis, 231(2), 323–333.

    Article  CAS  PubMed  Google Scholar 

  7. Saba, L., Raz, E., Grassi, R., Di Paolo, P. L., Iacomino, A., Montisci, R., et al. (2013). Association between the volume of carotid artery plaque and its subcomponents and the volume of white matter lesions in patients selected for endarterectomy. AJR. American Journal of Roentgenology, 201(5), W747–W752.

    Article  PubMed  Google Scholar 

  8. Gać, P., Jaźwiec, P., Mazur, G., Poręba, R. (2015). Exposure to cigarette smoke and the morphology of atherosclerotic plaques in the extracranial arteries assessed by computed tomography angiography in patients with essential hypertension. Cardiovascular Toxicology. Epub ahead of print.

  9. Arjmand Shabestari, A. (2013). Coronary artery calcium score: A review. Iranian Red Crescent Medial Journal, 15(12), e16616.

    Google Scholar 

  10. Agatston, A. S., Janowitz, W. R., Hildner, F. J., Zusmer, N. R., Viamonte, M., Jr., & Detrano, R. (1990). Quantification of coronary artery calcium using ultrafast computed tomography. Journal of the American College of Cardiology, 15(4), 827–832.

    Article  CAS  PubMed  Google Scholar 

  11. Berland, L. L., & Smith, J. K. (1998). Multidetector-array CT: Once again, technology creates new opportunities. Radiology, 209(2), 327–329.

    Article  CAS  PubMed  Google Scholar 

  12. Kwee, R. M. (2010). Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms. Journal of Vascular Surgery, 51(4), 1015–1025.

    Article  PubMed  Google Scholar 

  13. Jaźwiec, P., Gać, P., Jurdziak, M., Poręba, M., Mazur, G., Sobieszczańska, M., et al. (2015). Volume of carotid bodies and cardiac autonomic function in patients with essential hypertension. Autonomic Neuroscience, 190, 26–32.

    Article  PubMed  Google Scholar 

  14. North American Symptomatic Carotid Endarterectomy Trial Collaborators. (1991). Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. New England Journal of Medicine, 325(7), 445–453.

    Article  Google Scholar 

  15. Cardoso, C. R., Marques, C. E., Leite, N. C., & Salles, G. F. (2012). Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients. Journal of Hypertension, 30(5), 940–947.

    Article  CAS  PubMed  Google Scholar 

  16. Jiang, C. Q., Xu, L., Lam, T. H., Lin, J. M., Cheng, K. K., & Thomas, G. N. (2010). Smoking cessation and carotid atherosclerosis: the Guangzhou Biobank Cohort Study—CVD. Journal of Epidemiology and Community Health, 64(11), 1004–1009.

    Article  CAS  PubMed  Google Scholar 

  17. Kaźmierski, R., Michalak, S., & Kozubski, W. (2011). Ultrasound-based markers of carotid atherosclerosis correlate well with the number of classical atherosclerotic risk factors. Neurologia i Neurochirurgia Polska, 45(4), 317–327.

    Article  PubMed  Google Scholar 

  18. Kweon, S. S., Lee, Y. H., Shin, M. H., Choi, J. S., Rhee, J. A., Choi, S. W., et al. (2012). Effects of cumulative smoking exposure and duration of smoking cessation on carotid artery structure. Circulation Journal, 76(8), 2041–2047.

    Article  PubMed  Google Scholar 

  19. Johnson, H. M., Piper, M. E., Jorenby, D. E., Fiore, M. C., Baker, T. B., & Stein, J. H. (2010). Risk factors for subclinical carotid atherosclerosis among current smokers. Preventive Cardiology, 13(4), 166–171.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Yerly, P., Rodondi, N., Viswanathan, B., Riesen, W., Vogt, P., & Bovet, P. (2013). Association between conventional risk factors and different ultrasound-based markers of atherosclerosis at carotid and femoral levels in a middle-aged population. International Journal of Cardiovascular Imaging, 29(3), 589–599.

    Article  PubMed  Google Scholar 

  21. van Gils, M. J., Bodde, M. C., Cremers, L. G., Dippel, D. W., & van der Lugt, A. (2013). Determinants of calcification growth in atherosclerotic carotid arteries; a serial multi-detector CT angiography study. Atherosclerosis, 227(1), 95–99.

    Article  PubMed  Google Scholar 

  22. Vukadinovic, D., Rozie, S., van Gils, M., van Walsum, T., Manniesing, R., van der Lugt, A., et al. (2012). Automated versus manual segmentation of atherosclerotic carotid plaque volume and components in CTA: Associations with cardiovascular risk factors. International Journal of Cardiovascular Imaging, 28(4), 877–887.

    Article  PubMed  Google Scholar 

  23. Dores, H., de Araújo Gonçalves, P., Ferreira, A. M., Carvalho, M. S., Sousa, P. J., Cardim, N., et al. (2015). Performance of traditional risk factors in identifying a higher than expected coronary atherosclerotic burden. Revista Portuguesa de Cardiologia, 34(4), 247–253.

    Article  PubMed  Google Scholar 

  24. Hirooka, N., Kadowaki, T., Sekikawa, A., Ueshima, H., Choo, J., Miura, K., et al. (2013). Influence of cigarette smoking on coronary artery and aortic calcium among random samples from populations of middle-aged Japanese and Korean men. Journal of Epidemiology and Community Health, 67(2), 119–224.

    Article  PubMed  Google Scholar 

  25. Monti, M., Monti, A., Murdolo, G., Di Renzi, P., Pirro, M. R., Borgognoni, F., et al. (2014). Correlation between epicardial fat and cigarette smoking: CT imaging in patients with metabolic syndrome. Scandinavian Cardiovascular Journal, 48(5), 317–322.

    Article  PubMed  Google Scholar 

  26. Shaw, L. J., Raggi, P., Callister, T. Q., & Berman, D. S. (2006). Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokers. European Heart Journal, 27(8), 968–975.

    Article  PubMed  Google Scholar 

  27. Szarejko-Paradowska, A., Gluba-Brzózka, A., Pietruszyński, R., Rysz, J. (2015). Assessment of the relationship between selected cardiovascular risk factors and the indices of intima-media thickness and coronary artery calcium score in various stages of chronic kidney disease. International Urology Nephrology. Epub ahead of print.

  28. Mughal, M. M., Khan, M. K., DeMarco, J. K., Majid, A., Shamoun, F., & Abela, G. S. (2011). Symptomatic and asymptomatic carotid artery plaque. Expert Review of Cardiovascular Therapy, 9(10), 1315–1330.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kallio, K., Jokinen, E., Saarinen, M., Hämäläinen, M., Volanen, I., Kaitosaari, T., et al. (2010). Arterial intima-media thickness, endothelial function, and apolipoproteins in adolescents frequently exposed to tobacco smoke. Circulation: Cardiovascular Quality and Outcomes, 3(2), 196–203.

    Google Scholar 

  30. Yang, B., Li, M., Chen, B., Xu, Y., & Li, T. D. (2012). Deterioration of endothelial function and carotid intima-media thickness in Tibetan male adolescents exposed to second-hand smoke. Journal of Renin-Angiotensin-Aldosterone System, 13(4), 413–419.

    Article  Google Scholar 

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Correspondence to Paweł Gać.

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Gać, P., Jaźwiec, P., Mazur, G. et al. Exposure to Cigarette Smoke and the Carotid Arteries Calcification Index in Patients with Essential Hypertension. Cardiovasc Toxicol 17, 335–343 (2017). https://doi.org/10.1007/s12012-016-9391-x

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  • DOI: https://doi.org/10.1007/s12012-016-9391-x

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