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Head motion evaluation and correction for PET scans with 18F-FDG in the Japanese Alzheimer’s disease neuroimaging initiative (J-ADNI) multi-center study

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Abstract

Objective

Head motion during 30-min (six 5-min frames) brain PET scans starting 30 min post-injection of FDG was evaluated together with the effect of post hoc motion correction between frames in J-ADNI multicenter study carried out in 24 PET centers on a total of 172 subjects consisting of 81 normal subjects, 55 mild cognitive impairment (MCI) and 36 mild Alzheimer’s disease (AD) patients.

Methods

Based on the magnitude of the between-frame co-registration parameters, the scans were classified into six levels (A–F) of motion degree. The effect of motion and its correction was evaluated using between-frame variation of the regional FDG uptake values on ROIs placed over cerebral cortical areas.

Result

Although AD patients tended to present larger motion (motion level E or F in 22 % of the subjects) than MCI (3 %) and normal (4 %) subjects, unignorable motion was observed in a small number of subjects in the latter groups as well. The between-frame coefficient of variation (SD/mean) was 0.5 % in the frontal, 0.6 % in the parietal and 1.8 % in the posterior cingulate ROI for the scans of motion level 1. The respective values were 1.5, 1.4, and 3.6 % for the scans of motion level F, but reduced by the motion correction to 0.5, 0.4 and 0.8 %, respectively. The motion correction changed the ROI value for the posterior cingulate cortex by 11.6 % in the case of severest motion.

Conclusion

Substantial head motion occurs in a fraction of subjects in a multicenter setup which includes PET centers lacking sufficient experience in imaging demented patients. A simple frame-by-frame co-registration technique that can be applied to any PET camera model is effective in correcting for motion and improving quantitative capability.

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Acknowledgments

This study is a part of the “Translational Research Promotion Project/Research project for the development of a systematic method for the assessment of Alzheimer’s disease,” sponsored by the New Energy and Industrial Technology Development Organization (NEDO) of Japan. J-ADNI is also supported by a Grant-in-Aid for Comprehensive Research on Dementia from the Japanese Ministry of Health, Labour and Welfare, as well as by the grants from J-ADNI Pharmaceutical Industry Scientific Advisory Board (ISAB) companies. The authors would also like to thank the J-ADNI Imaging ISAB and other organizations for their support of this work.

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Authors and Affiliations

  1. Institute of Biomedical Research and Innovation, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan

    Yasuhiko Ikari, Tomoyuki Nishio, Yoko Makishi, Yukari Miya & Michio Senda

  2. National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-cho, Obu, Aichi, 474-8511, Japan

    Kengo Ito

  3. University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA

    Robert A. Koeppe

  4. Research Association for Biotechnology, 4-2 Nishishinbashi 2-Chome, Minato-Ku, Tokyo, 105-0003, Japan

    Yasuhiko Ikari, Tomoyuki Nishio, Yoko Makishi & Yukari Miya

  5. J-ADNI PET core, 35 Gengo, Morioka-cho, Obu, Aichi, 474-8511, Japan

    Kengo Ito

  6. J-ADNI PET QC core, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan

    Yasuhiko Ikari, Tomoyuki Nishio, Yoko Makishi, Yukari Miya & Michio Senda

Authors
  1. Yasuhiko Ikari
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  2. Tomoyuki Nishio
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  3. Yoko Makishi
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  4. Yukari Miya
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  5. Kengo Ito
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  6. Robert A. Koeppe
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  7. Michio Senda
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Corresponding author

Correspondence to Yasuhiko Ikari.

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Ikari, Y., Nishio, T., Makishi, Y. et al. Head motion evaluation and correction for PET scans with 18F-FDG in the Japanese Alzheimer’s disease neuroimaging initiative (J-ADNI) multi-center study. Ann Nucl Med 26, 535–544 (2012). https://doi.org/10.1007/s12149-012-0605-4

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  • DOI: https://doi.org/10.1007/s12149-012-0605-4

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