Abstract
Background
Juvenile xanthogranuloma (JXG) is a disorder of histiocyte proliferation. Most cases present with a solitary cutaneous lesion. JXG with systemic involvement is rare with significant morbidity. Intracranial solitary JXG may be misdiagnosed before operation.
Methods
A 5-month-old boy showed an elevated anterior fontanel but no other abnormalities on admission. Brain MRI showed a large mass in the right parietal region.
Results
The tumor was removed with the encroached meninges. A JXG in the right parietal region was diagnosed pathologically.
Conclusion
Total excision of the tumor may be curative with a prerequisite of ensuring normal vital signs and nervous function.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Freyer DR, Kennedy R, Bostrom BC, Kohut G, Dehner LP. Juvenile xanthogranuloma: forms of systemic disease and their clinical implications. J Pediatr 1996;129:227–237.
Tan MH. Juvenile xanthogranuloma of the pancreas: a case report and review of literature. J Chin Clin Med Abstract 2004;1:25–26.
Gutnik H, Dolenc-Strazar Z, Popovic M. September 2000: 15 year old girl with intracranial lesion. Brain Pathol 2001;11: 123–125.
Schultz KD Jr, Petronio J, Narad C, Hunter SB. Solitary intracerebral juvenile xanthogranuloma. Case report and review of the literature. Pediatr Neurosurg 1997;26:315–321.
Ashley WW Jr, Narayan P, Park TS, Tu PH, Perry A, Leonard JR. Incidental pediatric intraparenchymal xanthogranuloma: case report and review of the literature. J Neurosurg 2005; 102(3 Suppl):307–310.
Jung CS, Schänzer A, Hattingen E, Plate KH, Seifert V. Xanthogranuloma of the sellar region. Acta Neurochir (Wien) 2006;148:473–477.
Pimentel J, Fernandes A, Távora L, Miguéns J, Lobo Antunes J. Benign isolated fibrohistiocytic tumor arising from the central nervous system. Considerations about two cases. Considerations about two cases. Clin Neuropathol 2002;21:93–98.
Nakasu S, Tsuji A, Fuse I, Hirai H. Intracranial solitary juvenile xanthogranuloma successfully treated with stereotactic radiosurgery. J Neurooncol 2007;84:99–102.
Ladisch S. Histiocytosis syndrome of childhood. Nelson textbook of pediatrics, 17th ed. An Imprint of Elsevier Science, 1727–1730.
Eggli KD, Caro P, Quiogue T, Boal DK. Juvenile xanthogranuloma: non-X histiocytosis with systemic involvement. Pediatr Radiol 1992;22:374–376.
Ernemann U, Skalej M, Hermisson M, Platten M, Jaffe R, Voigt K. Primary cerebral non-Langerhans cell histiocytosis: MRI and differential diagnosis. Neuroradiology 2002;44: 759–763.
Nakatani T, Morimoto A, Kato R, Tokuda S, Sugimoto T, Tokiwa K, et al. Successful treatment of congenital systemic juvenile xanthogranuloma with Langerhans cell histiocytosis-based chemotherapy. J Pediatr Hematol Oncol 2004;26:371–374.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sun, LP., Jin, HM., Yang, B. et al. Intracranial solitary juvenile xanthogranuloma in an infant. World J Pediatr 5, 71–73 (2009). https://doi.org/10.1007/s12519-009-0015-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12519-009-0015-4