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Brain MRI, Tc-99m HMPAO SPECT and F-18 FP-CIT PET/CT Findings in a Patient with Wilson Disease: A Case Report

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Abstract

A 34-year-old female had experienced head and hand tremors with a dystonic component for 8 months. Brain MRI showed T2 high signal intensity in the periaqueductal region, dorsal midbrain and dorsal upper pons. No abnormal uptake was noted on Tc-99m HMPAO SPECT or F-18 FP-CIT PET/CT. Wilson disease was diagnosed according to the 2008 consensus guideline from the American Association for the Study of Liver Disease and 2012 guideline from the European Association for the Study of the Liver. This case demonstrates T2 signal change in the basal ganglia, excluding the putamen, in a Wilson disease patient with relatively severe clinical findings, but normal Tc-99m HMPAO SPECT and F-18 FP-CIT PET/CT.

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Ethics Statement

This study was approved by the ethics committee in our hospital and was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Conflict of Interest

Seungyoo Kim, In Uk Song, Yong An Chung, Eun Kyung Choi and Jin Kyoung Oh declare that they have no conflict of interest.

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Correspondence to Jin Kyoung Oh.

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Kim, S., Song, I.U., Chung, Y.A. et al. Brain MRI, Tc-99m HMPAO SPECT and F-18 FP-CIT PET/CT Findings in a Patient with Wilson Disease: A Case Report. Nucl Med Mol Imaging 48, 303–305 (2014). https://doi.org/10.1007/s13139-014-0290-4

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  • DOI: https://doi.org/10.1007/s13139-014-0290-4

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