Expression of APP in the early stage of brain damage

doi:10.1016/0006-8993(91)91558-I

Brain Research

Volume 563, Issues 1–2, 1 November 1991, Pages 334-338

https://doi.org/10.1016/0006-8993(91)91558-I Get rights and content

Abstract

We immunocytochemically studied the expression of various epitopes of amyloid ß/A4 protein precursor (APP) after brain damage by kainic acid injection. After 3 h, APP₆₉₅ rapidly accumulated in dystrophic neurites near the damaged site. After 3 days, APP with Kunitz-type protease inhibitor domain was expressed in reactive astrocytes in the lesion and ipsilateral hippocampus. APP rapidly accumulated in dystrophic neurites, and different types of APP were expressed in different cell types in the damaged brain.

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Short communicationExpression of APP in the early stage of brain damage

Abstract

Neuron

Biochem. Biophys. Res. Commun.

Brain Research

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FEBS Lett.

Cell

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Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice

Short communication
Expression of APP in the early stage of brain damage