Elsevier

Brain Research

Volume 577, Issue 1, 10 April 1992, Pages 36-40
Brain Research

Convulsive seizures in rats induced byN-methyl-d-aspartate injection into the massa intermedia

https://doi.org/10.1016/0006-8993(92)90534-GGet rights and content

Abstract

The behavioral and electroencephalographic effects ofN-methyl-d-aspartate (NMDA, 25 nmol/1 μl) injection into the massa intermedia (MI) was examined in rats. The injection caused violent running/jumping and shrill vocalization without evidence of EEG seizure in the hippocampus (HP) and amygdala (AM). Animals with the injection site located in the reuniens nucleus subsequently developed generalized tonic and then clonic seizure, leading to fatal status epilepticus in some animals. Intermittent or continuous EEG discharge in the limbic system was found during clonic seizures. These findings suggest that the NMDA receptor in the reuniens nucleus in the MI participates in the generation and expression of convulsive seizure in rats.

References (29)

  • DempsyE.W. et al.

    The production of rhythmically recurrent cortical potentials after localized thalamic stimulation

    Am. J. Physiol.

    (1942)
  • EharaY. et al.

    N-Methyl-d-aspartate injection into massa intermedia precipitates limbic seizure

    Epilepsia

    (1989)
  • HerkenhamM.

    The connections of the nucleus reuniens thalami: evidence for direct thalamo-hippocampal pathway in the rat

    J. Comp. Neurol.

    (1978)
  • JacquetF.J. et al.

    Paradoxical effects after microinjection in the periaqueductal gray matter in the rat

    Science

    (1974)
  • Cited by (0)

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