Short communicationCerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures☆
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Cited by (40)
Pathophysiology
2018, Volpe's Neurology of the NewbornAlteration of amino acid neurotransmitters in brain tissues of immature rats treated with realgar
2012, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Moreover, amino acid neurotransmitters are closely linked to the vulnerability of the immature brain to neuronal injury [12–14]. Data from studies performed in immature rats indicate that these animals may be especially susceptible to elevated concentrations of aspartate (Asp), glutamate (Glu), glutamine (Gln) and γ-aminobutyric acid (GABA) [15–18]. Therefore, the investigation of these amino acids and others is important to understand the evolution of developmental brain damage.
Treatment of the Term Newborn With Brain Injury: Simplicity As the Mother of Invention
2009, Pediatric NeurologyCitation Excerpt :With models designed to look at the implication of neonatal seizures consequent to a hypoxic-ischemic insult, again controversy exists. Cataltepe et al. [19-21] observed no increase in cell death or glutamate release as a result of bicuculline-induced seizures after hypoxia-ischemia in the 7-day old rat. In this model, however, brain injury was profound simply as a result of the hypoxia-ischemia, and hence further exacerbation of injury would have been difficult to determine.
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Supported by Grant #P01 HD30704 from the National Institute of Child Health and Human Development.
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Present address: Epilepsy Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA.