Mild postischemic hypothermia limits cerebral injury following transient focal ischemia in rat neocortex
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Responses of the Fetus and Neonate to Hypothermia
2017, Fetal and Neonatal Physiology, 2-Volume SetNeuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: Analysis from a neurophysiological perspective
2013, Brain ResearchCitation Excerpt :Several experimental studies have indicated that a decrease in brain temperature reduces cerebral infarction and is neuroprotective to the brain, while a mild increase in brain temperature can exacerbate the extent of ischemic neural injury (Busto et al., 1987; Minamisawa et al., 1990; Ginsberg et al., 1992; Kim et al., 1996; Baena et al., 1997). Therefore, previous studies have emphasized the clinical feasibility of systemic hypothermia for patients with brain injury and ischemia (Ginsberg et al., 1992; Clifton et al., 1993; Baena et al., 1997; Yanamoto et al., 1996; Schwab et al., 2001). Despite these favorable outcomes, systemic hypothermia can also lead to fatal complications, such as infection, cardiac arrhythmia, and disruption of blood coagulation (Clifton et al., 1993; Marion et al., 1993; Schubert, 1995).
Peri-infarct flow transients predict outcome in rat focal brain ischemia
2012, NeuroscienceCitation Excerpt :The damaged area was calculated by subtracting the area of the normal tissue in the hemisphere ipsilateral to the stroke from the area of the hemisphere contralateral to the stroke with the investigation made blindly. An edema index was calculated from the total volume of the hemisphere ipsilateral to the MCAO and the total volume of the contralateral hemisphere (Yanamoto et al., 1996), a technique validated by a combined MRI/water content study (Gerriets et al., 2004). Rats (n = 12) were anesthetized with 4% isoflurane for induction and maintained on 1.2–1.5% of isoflurane in 70% N2O and 30% O2 during surgery.
Therapeutic hypothermia: A state-of-the-art emergency medicine perspective
2012, American Journal of Emergency MedicineCitation Excerpt :However, long-term or goal-directed cooling studies demonstrated considerably reduced mortality (relative risk, 0.62; 95% confidence interval, 0.51-0.76) and a higher likelihood of good neurologic outcome (relative risk, 1.68, 95% confidence interval, 1.44-1.96) [114]. Animal models of TH have been shown to decrease the neurologic sequelae of acute cerebrovascular accidents [115,116]. Over a decade ago, Schwab and coworkers [117] demonstrated that TH reduced intracerebral pressure and levels of some of the extracellular excitatory amino acids in a cohort of 25 patients with an acute stroke of the middle cerebral artery territory.
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