Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations
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2015, Computational and Structural Biotechnology JournalCitation Excerpt :However, in cerebral ischemia caspase-3, the central effector caspase, is activated during the first postnatal week, but this gradually decreases as rats get older, and by postnatal day 60 there is no evidence that it is activated in neurons destined to die [19–22]. In acute neuronal injury in the adult rat brain, irreversibly damaged neurons are morphologically necrotic (Figs. 1–3) [10–14,23,24], and undergo a caspase-independent programmed cell death [23,25]. This caspase-independent programmed pathway is associated with activation of the Ca2 +-dependent cysteine protease calpain I [26–28].