Atrophy of the cerebellar vermis in ageing: A morphometric and histologic study
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Estimating brain age from structural MRI and MEG data: Insights from dimensionality reduction techniques
2021, NeuroImageCitation Excerpt :The brain structures that most reliably exhibited age-related changes included the putamen, thalamus, and caudate nucleus, which are important structures involved in relaying a variety of information across the brain, in sensorimotor coordination, and in higher cognitive functions (Grahn et al., 2008; Sefcsik et al., 2009; Sherman and Guillery, 2002). A number of stereological and MRI studies have reported atrophy in subcortical regions associated with aging, specifically in the putamen (Bugiani et al., 1978), amygdala (Coffey et al., 1992; Fjell et al., 2013), hippocampus (Fjell et al., 2013; Nobis et al., 2019), caudate nucleus (Krishnan et al., 1990), substantia nigra (McGeer et al., 1977), thalamus (Sullivan et al., 2004; Fjell et al., 2013), and cerebellum (Andersen et al., 2003; Good et al., 2001; Torvik et al., 1986). Recent studies using large subject cohorts have also reported an age-related decrease in the hippocampal and temporal lobe volumes (Nobis et al., 2019).
Age-dependent alterations in expression and co-localization of Pax6 and Ras-GAP in brain of aging mice
2018, Journal of Chemical NeuroanatomyDisentangling normal aging from Alzheimer's disease in structural magnetic resonance images
2015, Neurobiology of AgingCitation Excerpt :Volume loss is widespread in temporal areas and characterizes the shrinkage of hippocampi. Interestingly, the model displays an important atrophy pattern in the cerebellum, which is in agreement with observations previously reported in the literature (Koller et al., 1981; Luft et al., 1999; Torvik et al., 1986). Finally, other regions of volume loss were localized in the superior frontal cortex and in the cuneus, in agreement with previous findings on longitudinal atrophy in the ADNI healthy cohort (Fjell et al., 2009).