Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis
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Serum neurofilament light chain correlates with myelin and axonal magnetic resonance imaging markers in multiple sclerosis
2022, Multiple Sclerosis and Related DisordersHypoperfusion of the thalamus is associated with disability in relapsing remitting multiple sclerosis
2017, Journal of NeuroradiologyCitation Excerpt :These perfusion abnormalities may be related either to a primary vascular disturbance or to a metabolic dysfunction. Very few arguments support the first hypothesis although MS lesions are often centered by a venule [35]. Indeed, vascular pathology was never depicted.
The effect of venous anatomy on the morphology of multiple sclerosis lesions: A susceptibility-weighted imaging study
2016, Clinical RadiologyCitation Excerpt :Therefore, the relationship between MS lesions and venous structures has been the subject of much research. In histopathological studies, ovoid infiltration of macrophages and lymphocytes extending along the long axis of the central vein was detected in acute plaques, and myelin debris was found inside macrophages.6–9 Research on this topic is still ongoing.
The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis
2015, Progress in NeurobiologyCitation Excerpt :Nonetheless, the pathological examination of MS lesions can still provide valuable insights into the progression of the different types and/or stages of the disease process. The initial pathological classification of WM lesional activity was based on the presence of MHC class II receptors, adhesion molecules, cytokines, and the activation state of infiltrating lymphocytes and macrophages (Adams et al., 1989). However, this classification system was inadequate, as it could not discriminate between inflammatory and demyelinating activity within the lesions.
The Plasticity of Immune Cell Response Complicates Dissecting the Underlying Pathology of Multiple Sclerosis
2024, Journal of Immunology Research