Giant-cell reparative granuloma and related conditions affecting the jawbones

https://doi.org/10.1016/0030-4220(59)90215-4Get rights and content

Abstract

In a study of benign multinucleated-cell-containing lesions of the jaws, sixty-four examples of giant-cell reparative granuloma and only two of genuine giant-cell tumor of bone were encountered at the Mayo Clinic in a fifty-two-year period. Other benign giant-cell-containing lesions, such as aneurysmal bone cysts, cherubism, fibrous dysplasia, and malignant tumors, must be distinguished from giant-cell reparative granuloma.

The central and peripheral tumors of this giant-cell reparative process are so similar histopathologically that differentiation must be made on roentgenographic or surgical findings, and an arbitrary designation is sometimes necessary.

Giant-cell reparative granulomas respond favorably to conservative surgical removal, which is the treatment of choice.

References (13)

There are more references available in the full text version of this article.

Cited by (127)

  • Central giant cell granuloma in a paediatric maxilla: surgical management and a novel gene translocation

    2022, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  • Multiple versus solitary giant cell lesions of the jaw: Similar or distinct entities?

    2021, Bone
    Citation Excerpt :

    There is a great diversity in clinical presentation. The most common clinical feature is an asymptomatic swelling in the oral cavity [5–7,41,42]. However, some patients present with symptoms such as pain, tooth displacement and extension into soft tissue due to more aggressive processes.

  • Controversies in Oral and Maxillofacial Pathology

    2017, Oral and Maxillofacial Surgery Clinics of North America
    Citation Excerpt :

    AA GCLs are more commonly painful than MF GCLs, which are often detected via clinical or radiographic screening.62 Multiple reports have proposed that MF and AA GCLs are distinct entities, citing differences in clinical behavior and histologic features.61,65,67 Other reports postulate that the lesions exist on a continuum of the same disease process.60,68–71

View all citing articles on Scopus

Abridgment of thesis submitted by Dr. Austin to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Dentistry.

View full text