Multifocal chloromas of the brain

doi:10.1016/0090-3019(82)90042-8

Surgical Neurology

Volume 17, Issue 1, January 1982, Pages 47-51

https://doi.org/10.1016/0090-3019(82)90042-8 Get rights and content

Abstract

Sixteen months after the diagnosis of acute myelogenous leukemia, a 34-year-old woman developed a bizarre neurological syndrome. The CT scan showed multiple intraparenchymal masses in the right hemisphere, which at autopsy proved to be chloromas. This unusual complication of leukemia is discussed with reference to the 5 previously reported cases of intracranial chloromas.

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Vascular and Hematopoietic Neoplasms
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Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: A case report and review of the literature
2004, Journal of Clinical Neuroscience
Granulocytic sarcoma is a solid mass composed of premature precursors of granulocytic series cells in an extramedullary region. Intraparenchymal central nervous system localization without skull or meningeal invasion is extremely rare. Although different theories have been proposed to explain the mechanism of this unusual disorder, its exact mechanism is still unclear. Some degree of improvement can be achieved after surgery and radiotherapy but its prognosis is poor and most patients die within months. Nine cases of purely intraparenchymal granulocytic sarcomas have been reported in the literature. Here, we report the tenth case and review the current literature.
Chloroma of the cranium with durai involvement
1997, Journal of Clinical Neuroscience
An unusual case of chloroma (granulocytic sarcoma) of the cranium with involvement of underlying dura and presenting as an intracranial space occupying lesion, with no systemic evidence of myeloid leukaemia, is reported. Operative removal was followed by local radiation. The patient is well and no systemic evidence of leukaemia has been manifested nearly 4 years after operation. The literature is reviewed.
Case report: Granulocytic sarcoma (chloroma) presenting as a cerebellopontine angle mass
1992, Clinical Radiology
Granulocytic sarcomas (chloromas) are rare, solid extramedullary tumours composed of granulocyte precursors occurring in association with granulocytic leukaemia. A cerebellopontine angle granulocytic sarcoma in a 4-year-old child presenting with unilateral facial palsy is reported. The computed tomographic (CT) findings are described, with a review of the literature, and the significance of early diagnosis is discussed.
Magnetic resonance imaging of spinal intradural granulocytic sarcoma
1990, Magnetic Resonance Imaging
We report the case of a young black male with a spinal intradural granulocytic sarcoma proved by needle aspiration. The tumor was evaluated by myelography, computed tomography, and magnetic resonance imaging (MRI). Other than its rarity, the “dripping candle wax” appearance on MR T₁-weighted images and the lack of enhancement with Gd-DTPA makes this case unique. Progressive changes of the tumor following chemo- and radiotherapy were successfully demonstrated by MR.
Granulocytic sarcoma in childhood acute myelogenous leukemia
1989, Pediatric Neurology
A 12-year-old boy with acute myelogenous leukemia developed acute weakness and paresthesias of the lower extremities after lumbar puncture. Computed tomography and magnetic resonance imaging revealed 2 large paraspinal masses (granulocytic sarcoma) causing spinal cord compression. Treatment with corticosteroids, radiation therapy, and chemotherapy caused complete resolution of symptoms; there was no evidence of tumor on subsequent magnetic resonance imaging or at autopsy. Granulocytic sarcomas (chloromas) rarely involve the nervous system in patients with acute myelogenous leukemia, although with increased survival it is apparent that the incidence may be greater than previously believed. Central nervous system prophylaxis was not administered to our patient but may be recommended for future patients if systemic disease can be controlled. General features of central nervous system complications of acute myelogenous leukemia, characteristics of granulocytic sarcoma, and review of current radiographic techniques used in the evaluation of these tumors are discussed.

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Multifocal chloromas of the brain

Abstract

Blood

Pathogenesis of central nervous system infiltration in acute leukemia

Arch Pathol Lab Med

Spinal symptoms in chloroma and leukaemia

Brain

Intracerebellar chloroma (granulocytic sarcoma): a neurosurgical complication of acute myelocytic leukemia

Surg Neurol

Central nervous system chloromas preceding acute leukemia by one year

Neurology (Minneap)

Beteiligung des Nervensystems bei leukosen und malignen Lymphomen

Zentralbl Allg Pathol

Granulocytic sarcoma of the brain

Cancer