Original paperHypothyroidism following radiotherapy for head and neck cancer: multivariate analysis of risk factors
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Cited by (79)
Radiotherapeutic factors affecting the incidence of developing hypothyroidism after radiotherapy for head and neck squamous cell cancer
2018, Journal of the Egyptian National Cancer InstituteCitation Excerpt :Our results showed that 42.3% of the patients developed HT after a median 31 months of follow-up duration (range 18–37 months), and the incidence of HT was increased over the time as it was 24.6%, 36.5% and 42.3% at one, two and three years respectively after RT. Our results are somewhat in the range of other studies that reported post RT overall HT ranging from 17 to 47.7% [6,8,11–13,15,22–26]. As mentioned above, the follow-up duration in this study was relatively short.
Thyroid V40 Predicts Primary Hypothyroidism After Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma
2017, International Journal of Radiation Oncology Biology PhysicsRisk of hypothyroidism among patients with nasopharyngeal carcinoma treated with radiation therapy: A Population-Based Cohort Study
2017, Radiotherapy and OncologyCitation Excerpt :Combined therapy of RT and surgery is a risk factor for hypothyroidism in HNC patients [7,24,26]. The cause is believed to be thyroidectomy or hemithyroidectomy performed with laryngectomy or laryngopharyngoesophagectomy, or from damage to the feeding vessels of the thyroid gland [7]. However, radical excision of cervical lymph nodes without thyroidectomy did not increase the risk of hypothyroidism in NPC patients in the present study.
Dosimetric Predictors of Hypothyroidism After Radical Intensity-modulated Radiation Therapy for Non-metastatic Nasopharyngeal Carcinoma
2016, Clinical OncologyCitation Excerpt :As a large population of NPC survivors is expected after curative IMRT, long-term IMRT-related complications will gradually emerge. Hypothyroidism is a well-known long-term complication after radiation therapy to the head and neck region for lymphoma and head and neck cancers [9–11]. Previous studies have revealed some dosimetric parameters predictive of hypothyroidism in patients treated with 3DCRT and IMRT for their squamous cell head and neck cancers [12–18].
Hypothyroidism after radiotherapy of head and neck cancer
2014, Journal of Cranio-Maxillofacial SurgeryCitation Excerpt :Previous studies have shown considerable variation in the incidence of hypothyroidism. The incidence of 35% found in the RT group in our study is within a range from 3% to 47% cited in the literature (Vrabec and Heffron, 1981; Zohar et al., 1984; Liening et al., 1990; Weissler and Berry, 1991; Grande, 1992; Tami et al., 1992; Turner et al., 1995; Nishiyama et al., 1996; Kuten et al., 1996; August et al., 1996; Tell et al., 1997; Sinard et al., 2000; Mercado et al., 2001; Aich et al., 2005). This wide variation could be related to several factors, including, for example, heterogeneity in radiation technique, treatment dose, field size, and the interval of follow-up.
Does thyroid-sparing total laryngectomy decrease the risk of hypothyroidism?
2020, Journal of Laryngology and Otology