Are Ca2+-permeable kainate/AMPA receptors more abundant in immature brain?
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Why do febrile seizures involve specifically the developing brain?
2022, Febrile Seizures: New Concepts and ConsequencesGluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders
2021, Neurobiology of DiseaseInvestigation of GluA1 and GluA2 AMPA receptor subtype distribution in the hippocampus and anterior cingulate cortex of Long Evans rats during development
2020, IBRO ReportsCitation Excerpt :In the present work, GluA1 levels were significantly lower at P50 than P30. This is in line with previous investigations reporting a similar peak in GluA1 during early development, followed by a decrease into adulthood (Pellegrini-Giampietro et al., 1991, 1992a; Durand and Zukin, 1993; Martin et al., 1998; Ibaraki et al., 1999; Bian et al., 2012; Blair et al., 2013; McHail and Dumas, 2015). After P21, GluA3 expression overtakes and replaces GluA1 expression, which may serve to explain the decrease in GluA1 levels observed in adults (Durand and Zukin, 1993; Martin et al., 1998; Blair et al., 2013; McHail and Dumas, 2015).
Mechanisms of zinc modulation of olfactory bulb AMPA receptors
2019, NeuroscienceCitation Excerpt :Subunit composition of many neurotransmitter receptors is developmentally regulated. Data from other brain regions (e.g., hippocampus) suggest that expression of some AMPAR subunits (e.g., GluA2) (Pellegrini-Giampietro et al., 1992) and the flip and flop splice variants (Standley et al., 1995) change over time. However, little is known about any developmental changes in AMPAR subunit expression in the OB.
Cortical expression of AMPA receptors during postnatal development in a genetic model of absence epilepsy
2019, International Journal of Developmental NeuroscienceCitation Excerpt :Thus, put together, these results demonstrate that there is decreased expression of calcium permeable AMPARs (containing GluA1, 3 and 4 subunits) in the stargazer cortex prior to seizure onset, and the loss of these functional AMPARs in the stargazer somatosensory cortex is likely involved in the generation of SWDs in this model. Previous studies report that in the rodent brain, GluA1/4 AMPAR expression is higher than that of GluA2 during early development (Pickard et al., 2000), with levels of GluA2-containing AMPARs increasing after postnatal week 2 (Pellegrini-Giampietro et al., 1992; Zhu et al., 2000). These findings correspond with the consistent increase in GluA2 from PN7 into adulthood observed in the current study.