Actions of quinidine on potassium-delayed currents from isolated neurons of the cuban land snail Zachrysia guanensis

doi:10.1016/0742-8413(91)90239-P

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

Volume 99, Issue 3, 1991, Pages 263-267

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Abstract

1. Quinidine was applied to isolated, voltage-clamped, internally perfused neurons of Zachrysia guanensis.

2. The apparent inhibitory constant for the block of potassium delayed current was about 25 μM.

3. Quinidine induces an increase in the inactivation rate, probably independent of the effects upon current amplitude.

4. These results differ of those described in literature for other preparations, and may reflect specific properties of potassium-delayed channels of land snail neurons.

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Cited by (1)

Kinetic description of the activation of the delayed potassium current of the land snail Zachrysia guanensis in terms of the Hodgkin-Huxley formalism
1991, International Journal of Bio-Medical Computing
A description of the activation phase of the land snail Zachrysia guanensis delayed potassium current (I_K) is presented. It was found that I_K activation kinetics may be congruent with the Hodgkin-Huxley scheme if one assumes that the proportion of n particles at the beginning of the pulse is not zero. In this case I_K activation may be treated as carried by a homogeneous channel population, which may be relevant in view of the reported heterogeneity of the inactivation phase of this current.

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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology

Abstract

References (19)

The generation and modulation of endogenous rhythmicity in the Aplysia bursting pacemaker neurone R15

Prog. Biophys. molec. Biol.

Potassium outward current dependence on extracellular calcium in snail neuronal membrane

Neuroscience

Interactions of internal anions with potassium channels of the squid giant axon

J. gen. Physiol.

Interaction of tetraethylammonium ion derivatives with potassium channels of giant axons

J. gen. Physiol.

Toxins in the characterization of potassium channels

Trends neurol. Sci.

Potassium current suppression by quinidine reveals additional calcium currents in neuroblastoma cells

Actions of quinidine on ionic currents of molluscan pacemaker neurons

J. gen. Physiol.

Las neuronas de moluscos: Un modelo para el estudio de las toxinas de celenterados

Cienc. Biol.

Ionic Channels of Excitable Membranes

Cited by (1)

Kinetic description of the activation of the delayed potassium current of the land snail Zachrysia guanensis in terms of the Hodgkin-Huxley formalism