Cerebral blood flow tomography with xenon-133

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Cerebral blood flow (CBF) can be measured tomographically by inhalation of Xenon-133. The calculation is based on taking a sequence of tomograms during the wash-in and wash-out phase of the tracer. Due to the dynamic nature of the process, a highly sensitive and fast moving single photon emission computed tomograph (SPECT) is required. Two brain-dedicated SPECT systems designed for this purpose are mentioned, and the method is described with special reference to the limitations inherent in the soft energy of the 133Xe primary photons. CBF tomography can be used for a multitude of clinical and investigative purposes. This article discusses in particular its use for the selection of patients with carotid occlusion for extracranial/intracranial bypass surgery, for detection of severe arterial spasm after aneurism bleeding, and for detection of low flow areas during severe migraine attacks. The use of other tracers for CBF tomography using SPECT is summarized with emphasis on the 99mTc chelates that freely pass the intact blood-brain barrier. The highly sensitive brain-dedicated SPECT systems described are a prerequisite for achieving high resolution tomograms with such tracers.

References (23)

  • Høedt-RasmussenK et al.

    Regional cerebral blood flow in man determined by intraarterial injection of radioactive inert gas

    Circ Res

    (1966)
  • ConnHL

    Measurement of organ blood flow without blood sampling

    J Clin Invest

    (1955)
  • ObristWD et al.

    A simplified procedure for determining fast compartment rCBF's by 133Xenon inhalation, in Brain and Blood Flow

  • LassenNA et al.

    A fast single photon emission tomograph for regional cerebral blood flow studies in man

    J Comput Assist Tomogr

    (1978)
  • StokelyEM et al.

    A single photon dynamic computer-assisted tomograph (DCAT) for imaging brain function in multiple cross-sections

    J Comput Assist Tomogr

    (1980)
  • KannoI et al.

    Headtome: A hybrid emission tomograph for single photon and positron emission imaging of the brain

    J Comput Assist Tomogr

    (1981)
  • KuhlDE et al.

    Quantitative section scanning using orthogonal tangent correction

    J Nucl Med

    (1973)
  • UemuraK et al.

    A tomographic study of regional cerebral blood flow using 133Xe clearance and the Headtome. Method and clinical application for the patient with ischemic cerebrovascular disease

  • CelsisP et al.

    A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations

    J Comput Assist Tomogr

    (1981)
  • KetySS

    The theory and applications of the exchange of inert gas at the lungs and tissues

    Pharmacol Rev

    (1951)
  • KannoI et al.

    Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentration

    J Comput Assist Tomogr

    (1979)
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