Review articleNeural and behavioral substrates of mood and mood regulation
Introduction
This article summarizes the deliberations and recommendations of the workgroup on the Neural and Behavioral Substrates of Mood and Mood Regulation. The article is divided into two major sections. In the first section, we summarize the current status of the field, present our vision for the future, and in so doing, discuss the various challenges and available opportunities. The second section contains specific recommendations for National Institute of Mental Health (NIMH) priorities in these areas. In each section, we consider research using the following four approaches, which together constituted the subject matter of this workgroup: 1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental.
Section snippets
Behavioral and cognitive approaches
Research in this area has generated some consistent findings regarding the course and characteristics of depression (Abramson et al 2001) and bipolar disorder (BPD). Eight of these findings are enumerated here. We then describe our current knowledge base of cognitive and psychosocial processes involved in depression and BPD onset and maintenance. Finally, we explore opportunities for future research.
Recommendations for NIMH priorities
We provide recommendations in five specific areas: 1) the behavioral domain; 2) the neural domain; 3) the domain of behavioral-neural interaction; 4) training; and 5) dissemination.
Acknowledgements
This manuscript is one of ten prepared by workgroups under the auspices of the National Institute of Mental Health (NIMH) strategic planning initiative for mood disorders research. Each of the workgroups was given the specific charge to 1) review the state of their assigned area; 2) identify gaps and state a vision of where the field should be going and why; and 3) make general recommendations for NIMH to consider regarding research initiatives that would advance and improve the knowledge and
References (214)
- et al.
Suicidality and cognitive vulnerability to depression among college studentsA prospective study
J Adolesc
(1998) - et al.
Differential resting quantitative electroencephalographic alpha patterns in women with environmental chemical intolerance, depressives, and normals
Biol Psychiatry
(1998) - et al.
Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive disorder, and panic disorder
Neuropsychopharmacology
(1999) - et al.
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Biol Psychiatry
(1997) - et al.
Reduced volume of orbitofrontal cortex in major depression
Biol Psychiatry
(2002) - et al.
Regional brain asymmetries in major depression with or without an anxiety disorderA quantitative electroencephalographic study
Biol Psychiatry
(1997) - et al.
Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant
Biol Psychiatry
(2001) - et al.
Effect of sertraline on regional metabolic rate in patients with affective disorder
Biol Psychiatry
(1997) - et al.
Cognitive and emotional influences in anterior cingulate cortex
Trends Cognit Sci
(2000) - et al.
Interference and facilitation effects during selective attentionAn H215O PET study of Stroop task performance
Neuroimage
(1995)