Elsevier

Biological Psychiatry

Volume 52, Issue 6, 15 September 2002, Pages 478-502
Biological Psychiatry

Review article
Neural and behavioral substrates of mood and mood regulation

https://doi.org/10.1016/S0006-3223(02)01458-0Get rights and content

Abstract

A review of behavioral and neurobiological data on mood and mood regulation as they pertain to an understanding of mood disorders is presented. Four approaches are considered: 1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental. Within each of these four sections, we summarize the current status of the field and present our vision for the future, including particular challenges and opportunities. We conclude with a series of specific recommendations for National Institute of Mental Health priorities. Recommendations are presented for the behavioral domain, the neural domain, the domain of behavioral–neural interaction, for training, and for dissemination. It is in the domain of behavioral–neural interaction, in particular, that new research is required that brings together traditions that have developed relatively independently. Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals.

Introduction

This article summarizes the deliberations and recommendations of the workgroup on the Neural and Behavioral Substrates of Mood and Mood Regulation. The article is divided into two major sections. In the first section, we summarize the current status of the field, present our vision for the future, and in so doing, discuss the various challenges and available opportunities. The second section contains specific recommendations for National Institute of Mental Health (NIMH) priorities in these areas. In each section, we consider research using the following four approaches, which together constituted the subject matter of this workgroup: 1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental.

Section snippets

Behavioral and cognitive approaches

Research in this area has generated some consistent findings regarding the course and characteristics of depression (Abramson et al 2001) and bipolar disorder (BPD). Eight of these findings are enumerated here. We then describe our current knowledge base of cognitive and psychosocial processes involved in depression and BPD onset and maintenance. Finally, we explore opportunities for future research.

Recommendations for NIMH priorities

We provide recommendations in five specific areas: 1) the behavioral domain; 2) the neural domain; 3) the domain of behavioral-neural interaction; 4) training; and 5) dissemination.

Acknowledgements

This manuscript is one of ten prepared by workgroups under the auspices of the National Institute of Mental Health (NIMH) strategic planning initiative for mood disorders research. Each of the workgroups was given the specific charge to 1) review the state of their assigned area; 2) identify gaps and state a vision of where the field should be going and why; and 3) make general recommendations for NIMH to consider regarding research initiatives that would advance and improve the knowledge and

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