Cerebral sarcoidosis

doi:10.1016/S0007-0971(68)80014-2

British Journal of Diseases of the Chest

Volume 62, Issue 4, October 1968, Pages 195-199

https://doi.org/10.1016/S0007-0971(68)80014-2 Get rights and content

Summary

Cerebral sarcoidosis is reported in a woman of 32 years. The patient had suffered diabetes insipidus for more than 2 years, and shortly before death developed signs of meningo-encephalitis. Autopsy showed involvement of the meninges, brain and pituitary gland with sarcoidosis. Sarcoidosis of the central nervous system should be considered in a patient presenting with diabetes insipidus or obscure neurological signs.

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Sarcoidosis with involvement of the nervous system
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Sarcoidosis with involvement of the nervous system: report of nine cases
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There are more references available in the full text version of this article.

Cited by (14)

A case of subcortical dementia due to sarcoidosis of the hypothalamus and fornices
1983, Brain and Cognition
A patient with sarcoidosis involving predominantly the hypothalamus and fornices was evaluated for dementia. He showed a relative sparing of fund of knowledge and orientation. Memory skills, particularly short-term memory, were severely impaired. Behavioral changes included apathy and a lack of spontaneity. Insight was relatively preserved. The pattern of his deficits showed some similarities to the pattern reported in patients with Huntington's disease and was different from that described in Alzheimer's disease. The dementia caused by subcortical pathology may differ in important respects from that caused by diffuse cortical dysfunction.
Central nervous system sarcoidosis
1983, General Hospital Psychiatry
Sarcoidosis may involve the central nervous system (CNS) in approximately 5% of cases. Three levels of neurological involvement are possible and include cranial nerve abnormalities, peripheral neuropathies, and lesions of the brain, spinal cord, and meninges. In addition to abnormal neurological findings, psychiatric presentations of CNS sarcoidosis include symptoms of delirium, dementia, depression, personality changes, and psychosis. The diagnosis usually rests on neurological, psychiatric, and cerebrospinal fluid (CSF) abnormalities with a history of sarcoidosis in other organ systems. The CSF, however, may be normal in as many as 30# of cases. The complexities of the illness and the difficulties that may be encountered in making the diagnosis are illustrated with a case of suspected CNS sarcoidosis that presented with delirium and choreoathetosis. The use of steroids as the mainstay of treatment is also discussed.
Partial hypopituitarism and possible hypothalamic involvement in sarcoidosis. Report of a case and review of the literature
1977, The American Journal of Medicine
A 20 year old patient with generalized sarcoidosis is described. Sudden cessation of growth, and failure of development of secondary sex characteristics were noted at age 16. Tests of hypothalamicpituitary function documented a deficiency of growth hormone and adrenocorticotropin reserve. The patient had osteolytic lesions in the calvarium of his skull, a previously unreported finding in patients with hypopituitarism secondary to sarcoidosis. This is the 29th reported case of sarcoidosis and hypopituitarism, and the first in which growth hormone deficiency is documented. The literature pertaining to sarcoidosis and hypopituitarism, and sarcoid involvement of the skull is reviewed.
Radiological manifestations of neurosarcoidosis: Report of three cases and review of literature
1974, Clinical Radiology
The neuroradiological findings in three anergic patients with pituitary and endocrine disturbances, as well as typical pulmonary findings of sarcoidosis during the course of their disease, are presented. Biopsy confirmation of the intracranial lesion was obtained in one case. The pertinent literature is reviewed.
Suprasellar calcification was found in one case. Polytome pneumoencephalography demonstrated suprasellar lesions in two cases. One case had angiographic findings which could represent a type of arteritis not previously described in association with neurosarcoidosis.
The authors conclude that patients with sarcoidosis and neurological changes should undergo thorough neuroradiological evaluation to define the extent of disease. This should include, in addition to the usual plain skull radiographs, arteriography and pneumoencephalography with tomography.
Clinical, imaging, and histological presentations and outcomes of stroke related to sarcoidosis
2018, Journal of Neurology
Cerebrovascular manifestations of neurosarcoidosis: An underrecognized aspect of the imaging spectrum
2018, American Journal of Neuroradiology

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Cerebral sarcoidosis

Summary

Greenfield's Neuropathology

Sarcoidosis of the central nervous system: A case with postmortem studies

Arc. Neurol. (Chic.)

Sarcoidosis with involvement of the nervous system

Brain

Hypothalamic lesion caused by Boeck's sarcoid

J. clin. Endocr.

Sarcoidosis with involvement of the nervous system: report of nine cases

Arch. Neurol. Psychiat. (Chic.)