Pharmacology lettersImplication of adenosine A2A receptors in hypotension-induced vasodilation and cerebral blood flow autoregulation in rat pial arteries
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2018, Journal of HepatologyThe adenosine neuromodulation system in schizophrenia
2014, International Review of NeurobiologyCitation Excerpt :A2AR are also located in astrocytes (Daré, Schulte, Karovic, Hammarberg, & Fredholm, 2007; Matos, Augusto, Santos-Rodrigues, et al., 2012; Nishizaki et al., 2002) where they control the uptake of glutamate (Matos, Augusto, Santos-Rodrigues, et al., 2012) and likely several other functions thanks to their ability to control Na+/K+-ATPase (Matos, Augusto, Agostinho, Cunha, & Chen, 2013), the main energizing systems supporting astrocytic functions (Benarroch, 2011; Kirischuk, Parpura, & Verkhratsky, 2012). Finally, A2AR also play a role in defining hemodynamic responses thanks to their involvement in the vasodilation of brain vessels (Kusano et al., 2010; Ngai, Coyne, Meno, West, & Winn, 2001; Shin, Park, & Hong, 2000). The interest in the adenosine neuromodulation system in mood-related disorders was prompted by the particularly high density of A2AR in dopamine-rich brain regions, namely in the basal ganglia (Schiffmann, Fisone, Moresco, Cunha, & Ferré, 2007; Svenningsson, Le Moine, Fisone, & Fredholm, 1999).
Interaction of adenosine and naloxone on regional cerebral blood flow in morphine-dependent rats
2006, Brain ResearchCitation Excerpt :Adenosine is an endogenous vasodilator considered to be involved in the local blood flow regulation of various tissues. Adenosine induced vasodilatation in the rats pial artery is mediated via activation of adenosine A2a and A2b receptors with different mechanisms (Shin et al., 2000; Ukena et al., 1987). On the other hand, adenosine is an inhibitory neurotransmitter in the central nervous system.
Identification of adenosine A1 and A3 receptor subtypes in rat pial and intracerebral arteries
2004, Neuroscience LettersDietary caffeine consumption modulates fMRI measures
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