QUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY

doi:10.1016/S0140-6736(86)90467-8

The Lancet

Volume 328, Issue 8515, 8 November 1986, Pages 1063-1066

https://doi.org/10.1016/S0140-6736(86)90467-8 Get rights and content

Abstract

New apparatus was made whereby indices of cerebral oxygenation and haemodynamics in sick newborn infants could be quantified by near infrared (NIR) spectrophotometry and displayed instantaneously at the cotside. The indices included oxygenated haemoglobin, reduced haemoglobin, oxidised cytochrome aa₃, and total haemoglobin concentration: cerebral blood volume, mixed cerebral venous saturation, and changes in cerebral blood flow were then derived. Striking changes were observed in response to alterations in arterial oxygen saturation and carbon dioxide tension and to tilting of the infant. Abnormal responses were detected in cerebral oedema following birth asphyxia, patent ductus arteriosus, and cystic encephalomalacia. NIR spectrophotometry provides valuable quantitative data at the cotside for the management of sick infants and for exploring the pathophysiology of damage to the brain.

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Citation Excerpt :
The sensor containing a light-emitting diode and 2 distant sensors was attached to the frontoparietal side of the head.30 rScO2 was calculated from the differential signals obtained from the sensor, expressed as venous-weighted percent oxygenated hemoglobin [oxygenated hemoglobin/total hemoglobin (oxygenated hemoglobin + deoxygenated hemoglobin)].31 An elastic bandage was used for sensor fixation and replaced every 6 hours from left-to-right or right-to-left to prevent skin lesions.
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Preliminary CommunicationQUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY

Abstract

Noninvasive infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters

Science

Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations

Pediatrics

Preliminary Communication
QUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY