Early ReportPoliomyelitis-like illness due to Japanese encephalitis virus
Introduction
Since the WHO initiative for global eradication of polio, the incidence of poliomyelitis has fallen greatly in many tropical areas, yet in some countries acute flaccid paralysis remains a common disease in childhood.1 In Vietnam, 464 cases of acute flaccid paralysis were reported in 1995; 132 (28%) were diagnosed clinically as poliomyelitis,2 yet poliovirus was isolated in only seven (1·5%) cases.2 Many patients with acute flaccid paralysis are diagnosed clinically as having Guillain-Barré syndrome or poliomyelitis, although in some the diagnosis remains uncertain. As part of a 1-year prospective study in southern Vietnam of infections of the central nervous system, we investigated the 22 children who presented with acute flaccid paralysis for other causes of the disorder, including infection with Japanese encephalitis virus (JEV). This flavivirus is endemic in southeast Asia and characteristically causes severe meningo-encephalomyelitis, but it has not been described previously as a cause of acute flaccid paralysis.
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Patients and methods
The study was done at the Centre for Tropical Diseases—an infectious diseases hospital that is a referral centre for much of southern Vietnam. The study was approved by the hospital's scientific and ethics committee, and consent for inclusion was obtained from the accompanying parent. For 1 year, up to December, 1995, we studied all children admitted with acute flaccid paralysis, defined as a rapid onset of weakness in one or more limbs with reduced or absent reflexes, flaccid tone, and no
Results
Of 150 children with suspected central-nervous-system infections, 22 (15%) met the case-definition for acute flaccid paralysis. 12 (55%) patients had evidence of acute infection with JEV, eight had no evidence of JEV infection, and in two the results were non-diagnostic (acute CSF and serum sample negative; table 1). The median IgM titre was 182 (range 43–252) units in serum and 150 (30–412) units in CSF. Three patients had a negative admission sample and seroconverted during the first week.
Discussion
More than half the children with acute flaccid paralysis seen during 1 year in this referral hospital were infected with JEV. This zoonotic flavivirus is transmitted between domestic animals and birds by culex mosquitoes. Human beings are an incidental host. The geographical distribution of JEV infections has expanded over the past 50 years to include all of southeast Asia, much of China, and most of the Indian subcontinent.11 Although a formalin-inactivated vaccine has been available for more
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