Elsevier

Journal of Infection

Volume 20, Issue 1, January 1990, Pages 51-52, IN1-IN3, 53-54
Journal of Infection

Case report
Progressive multifocal leukoencephalopathy-remission with cytarabine

https://doi.org/10.1016/S0163-4453(90)92324-EGet rights and content

Summary

A 51-year-old women who was in complete remission from non-Hodgkin's lymphoma, developed a rapidly progressive dementia. Progressive multifocal leukoencephalopathy (PML) was diagnosed on the basis of a rising antibody titre to JC polyomavirus in cerebro-spinal fluid and serum and the presence of diffuse white matter changes on magnetic resonance imaging. She was treated initially with intravenous cytarabine and showed minimal improvement. Rapid improvement occurred when intrathecal cytarabine was added and the patient is in complete remission from both lymphoma and PML 20 months later.

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