On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder

doi:10.1016/S0278-5846(00)00146-9

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volume 25, Issue 1, January 2001, Pages 5-26

https://doi.org/10.1016/S0278-5846(00)00146-9 Get rights and content

Abstract

1.
The objective of the present study was to compare the phenomenology and pathophysiology of obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder/deficits in attention, motor control and perception (ADHD/DAMP).
2.
Through detailed studies of the literature on OCD and ADHD/DAMP, the phenomenology of these two conditions is compared, and possible underlying pathophysiological mechanisms involving interactions between glutamate, dopamine, serotonin and acetylcholine are discussed, with emphasis on OCD. The present paper also discusses possible mechanisms of action for current pharmacological treatments of OCD and ADHD, as well as possible future treatment strategies for these disorders.
3.
OCD and ADHD/DAMP are common neuropsychiatric conditions which in many regards appear to be each other's antipodes with respect to clinical manifestations, associated personality traits and brain biochemistry, notably prefrontal cortical glutamate activity. Future pharmacological treatments of these disorders may involve manipulations with glutamate, dopamine D1, serotonin 22A and nicotine receptors.
4.
It appears that OCD is a hyperglutamatergic and ADHD a hypoglutamatergic condition, with prefrontal brain regions being especially affected.

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On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder

Abstract

TINS

Neuropsychopharmacology

Psychiatric Clinics of North America. Obsessional Disorders

Psychiatry Res

TINS

TINS

Adv Pharmacology

Lancet

Psychiatr Clin North Am

J Am Acad Child Adolesc Psychiat

Biol Psychiatry

J Am Acad Child Adolesc Psychiatry

Lancet

Eur J Pharmacol

Eur J Pharmacol

Biol Psychiatry

J Am Acad Child Adolesc Psychiatry

Biol Psychiatry

Neuropharmacology

Lancet

Striatal and nigral neuron subpopulations in rigid Huntington's disease. Implications for the functional anatomy of chorea and rigidity-akinesia

Ann Neurol

Treatment of clozapine-induced obsessive-compulsive symptoms with sertraline

Am J Psychiatry

A case report of risperidone-induced obsessive-compulsive symptoms

J Clin Psychopharmacol

High-resolution brain SPECT imaging in ADHD

Annals of Clinical Psychiatry

Risperidone may worsen fluoxetine-treated OCD

J Clin Psychiatry

Emergence of obsessive compulsive symptoms during treatment with clozapine

J Clin Psychiatry

Caudate glucose metabolic rate changes with both drug and behavior for obsessive-compulsive disorder

Arch Gen Psychiatry

Local cerebral glucose metabolic rates in obsessive-compulsive disorder

Arch Gen Psychiatry

LSD treatment in a severe case of compulsive neurosis

Acta Psychiat Scand

The functional neuroanatomy of Tourette's syndrome: An FDG-PET study. I. Regional changes in cerebral glucose metabolism differentiating patients and controls

Neuropsychopharmacology

Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder

Arch Gen Psychiatry

Use of a nicotine receptor agonist in the treatment of obsession compulsive disorder

Hypothesis: Is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - serotonin interactions for pharmacotherapy

J Neural Transm

The selective 5-HT2A receptor antagonist MDL 100,907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse - implications for psychosis

J Neural Transm [Gen Sect]

Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

J Comp Neurol

Obsessive-compulsive disorder responsive to electroconvulsive therapy in an elderly woman

Southern Medical Journal

Addition of fluoxetine to clozapine

Am J Psychiatry

Neurosurgical therapy of obsessive-compulsive disorder

Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD)

Psychopharmacol Bull

Treatment of risperidone-induced obsessive-compulsive symptoms with sertraline

Am J Psychiatry

Differential response of psychotic and obsessive symptoms to risperidone in an adolescent

J Child Adolesc Psychopharmacol

Exacerbation of obsessive-compulsive symptoms associated with clozapine

Br J Psychiatry

Obsessive compulsive symptoms in Gilles de la Tourette syndome and obsessive compulsive disorder. Differences by diagnosis and family history

Am J Med Genet

Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourett's syndrome

Am J Psychiatry

Long-term stimulant treatment of children with attention-deficit hyperactivity symptoms

Arch Gen Psychiat

Treatment of obsessive-compulsive disorder by psychosurgery

Acta Psychiatr Scand

Maintenance ECT for refractory obsessive-compulsive disorder

Am J Psychiatry

Obsessive-compulsive disorder: A neuroethological perspective

Psychopharmacol Bull

Obsessive compulsive disorder and ventromedial frontal lesions: Clinical and neuropsychological findings

Am J Psychiatry