Research paperFixation-induced shrinkage of Reissner's membrane and its potential influence on the assessment of endolymph volume
References (11)
- et al.
Imaging the cochlea by magnetic resonance microscopy
Hear. Res.
(1994) Animal models of endolymphatic hydrops
Am. J. Otolaryngol.
(1982)- et al.
Time course of endolymph volume increase in experimental hydrops measured in vivo with an ionic volume marker
Hear. Res.
(1994) - et al.
Detection and quantification of endolymphatic hydrops in the guinea pig cochlea by magnetic resonance microscopy
Hear. Res.
(1995) - et al.
Ion transport mechanisms responsible for K+ secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro
Hear. Res.
(1995)
Cited by (25)
Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI
2015, Hearing ResearchCitation Excerpt :Endolymphatic hydrops in experimental models has to a large extent been demonstrated using histological analysis which requires several manipulations; fixation, decalcification, embedding, and sectioning. One concern with histological methods is thus that the degree of hydrops may be influenced by the fixation and processing [Brunschwig and Salt, 1997]. MRI studies on guinea pigs support however the induction of EH induced surgically or induced by other treatments [Zou et al., 2003a,b].
Endolymphatic Hydrops: Pathophysiology and Experimental Models
2010, Otolaryngologic Clinics of North AmericaCitation Excerpt :One concern with all these methods is whether the degree of hydrops was influenced by the fixation and processing methods. It was shown that dissected, fresh Reissner membrane segments in vitro underwent substantial shrinkage during fixation with some protocols, suggesting that the degree of hydrops could be underestimated based on measurements from fixed tissues.79 Recently, there have been major advances in MR imaging that have allowed endolymphatic hydrops to be visualized and quantified in the live ears of animals and humans.80–82