PATHOGENESIS OF BACTERIAL MENINGITIS
Section snippets
PATHOGENESIS OF BACTERIAL MENINGITIS
The development of bacterial meningitis progresses through four interconnected phases: (1) bacterial invasion of the host with subsequent infection of the CNS; (2) bacterial multiplication and induction of inflammation in the subarachnoid and ventricular space; (3) progression of inflammation with associated pathophysiologic alterations; and (4) development of neuronal damage (Fig. 1). The structure of this review follows this conceptual framework.
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Address reprint requests to Stephen L. Leib, MD, Institute for Medical Microbiology, University of Bern, Friedbühlstrasse 51, 3010 Bern, Switzerland, e-mail: [email protected]
This work was supported by Grants from the National Institutes of Health (NS34028 and NS35902) and from the Swiss National Science Foundation (NFPNR 38: 4038-52841)
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Institute for Medical Microbiology, University of Bern, Bern, Switzerland